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A new study has shown that the tumour-inhibiting gene TET2 is silenced in a large fraction of cases of acute lymphoblastic leukemia (ALL) in children. The scientists show that the gene can be reactivated by an existing drug, 5-azacytidine. The results suggest that 5-azacytidine may function as targeted therapy for […]

A small group of nerve cells in the brain determines whether an individual continues to consume alcohol even when it has negative consequences. This is the conclusion of a study carried out on rats by researchers at LiU. The scientists have identified a previously unknown mechanism that may be a […]

All other things being equal, more cells in the body undertaking more activity means a larger risk in any given period of time of one of those cells undergoing a cancerous mutation. Given this, larger and longer-lived species have necessarily evolved superior mechanisms of cancer suppression in order to avoid […]

In the course of examining gender differences on fly longevity, researchers here find sizable variations in life span between repeated studies. This variation is thought to derive from differences in maintaining a fly population, such as the dietary composition and season of the year. They suggest that this calls into […]

Findings suggest infection control measures against variants will need to continue in the post-vaccination era. The Delta variant of SARS-CoV-2, which has become the dominant variant in countries including India and the UK, has most likely spread through its ability to evade neutralising antibodies and its increased infectivity, say an […]

A biomarker in the brain predicts future cognitive decline in patients with the language form of Alzheimer’s disease (AD), reports a new Northwestern Medicine study. Northwestern Medicine scientists discovered the buildup of tau protein in the brain predicts the amount of future cognitive decline over one year in individuals with […]

Natural killer cells do not just kill cancer cells or cells infected with viruses, they also mediate a trade-off between wound healing and bacterial defense in skin wounds. If the healing process is accelerated, the immune defense is weakened, researchers at the University of Zurich have now shown. This has […]

Berkeley Lab researchers helped validate new AI-based algorithm, RosETTAFold, to generate hundreds of new protein structures. “The dream of predicting a protein shape just from its gene sequence is now a reality,” said Paul Adams, Associate Laboratory Director for Biosciences at Berkeley Lab. For Adams and other structural biologists who […]

Aging, especially in late life, is not a beautiful process for everyone. For many it causes a lot of suffering, including dementia. While the problems of aging still cannot be solved, scientists are developing tools to make it at least a little bit less painful. Researchers at the University of […]

Rheumatoid arthritis is a disease, which affects people’s joints, skin, eyes, lungs and some other organs. Usually rheumatoid arthritis is recognizable because of damaged joints, but it is a much more widely reaching autoimmune disease. That is why scientists at UCL are looking into the gut for the origins of […]