Related Science News – Page 99 – Innovita Research

Related Science News

October 15, 2020

Clues to Brain Development and Disease Emerge from 3D Epigenome Study

Risks for neuropsychiatric disorders including autism, schizophrenia and attention deficit hyperactivity disorder (ADHD) are in part genetically determined. Now UC San Francisco researchers are finding new clues to how these disorders unfold by focusing on the role of a little-studied form of DNA in early brain development. Like a late-night […]
October 15, 2020

Harnessing the power of nanobodies to rebuild kidneys

UW Medicine scientists are driving a bold, multi-partner experiment to stimulate the repair and regeneration of human kidney cells. A favorable outcome could jump-start a new therapy model for 850 million people worldwide who live with kidney disease. The National Institutes of Health recently announced the project’s funding: $4 million over five […]
October 15, 2020

Study: Racial disparities exist in cognitive health expectancies, despite educational attainment

There are more than 5 million Americans living with Alzheimer’s disease, and 50 million with other dementias, according to figures from the Alzheimer’s Association. Research into these diseases and how to prevent them is key as more and more Americans live longer, raising their risk for developing cognitive impairment. In a new […]
October 14, 2020

Cure found for rare form of inflammatory bowel disease

A rare genetic condition which causes inflammatory bowel disease can be successfully treated by bone marrow transplant, according to the University of Manchester and Manchester University NHS Foundation Trust researchers. The disease, called G6PC3 deficiency, affects around one in a million people and causes inflammation of the bowel, as well as lung infections. The […]
October 14, 2020

Scientists uncover new clues about Parkinson’s disease

Tool developed at MIT simultaneously measures chemical and electrical brain signals, revealing unexpectedly complex relationship between brain signals. As the brain processes information, electrical charges zip through its circuits and neurotransmitters pass molecular messages from cell to cell. Both forms of communication are vital, but because they are usually studied […]
October 14, 2020

Technique recovers lost single-cell RNA-sequencing information

Boosting the efficiency of single-cell RNA-sequencing helps reveal subtle differences between healthy and dysfunctional cells. Sequencing RNA from individual cells can reveal a great deal of information about what those cells are doing in the body. MIT researchers have now greatly boosted the amount of information gleaned from each of […]
October 14, 2020

To make mini-organs grow faster, give them a squeeze

The closer people are physical to one another, the higher the chance for exchange, of things like ideas, information, and even infection. Now researchers at MIT and Boston Children’s Hospital have found that, even in the microscopic environment within a single cell, physical crowding increases the chance for interactions, in […]
October 14, 2020

Childhood cancer program powered by genomics and philanthropy

Children with high-risk cancers have received effective treatments leading to complete or partial regression of their cancer thanks to a pioneering research program that tailors therapy based on the complete DNA sequence of a patient’s individual tumour. A report of 247 participants of the Zero Childhood Cancer Program published in […]
October 14, 2020

ADHD genetic risk score associated with intervention outcomes in autism.

Researchers from Karolinska Institutet demonstrate that genetic risk score for ADHD can influence how autistic individuals respond to standard interventions and the specific program on social skills training KONTAKT®. This study is now published in npj Genomic Medicine. “Our ultimate goal is to be able to use genetic information to […]
October 14, 2020

NIH-funded study links adolescent brain differences to increased waist circumference

Differences in the microstructure of the nucleus accumbens (NAcc), a region in the brain that plays an important role in processing food and other reward stimuli, predict increases in indicators of obesity in children, according to a study funded by the National Institute on Drug Abuse (NIDA) and nine other […]
October 14, 2020

University of Minnesota opens first of its kind clinical trial to treat metastatic GI cancers using CRISPR genetic engineering

reatment of metastatic gastrointestinal solid tumor cancer. The Phase II clinical trial, which will use cutting-edge CRISPR genetic engineering, has opened exclusively at the M Health Fairview University of Minnesota Medical Center, and has already begun enrolling patients. This trial comes on the heels of groundbreaking research from a consortia […]
October 13, 2020

Ancient tiny teeth reveal first mammals lived more like reptiles

Pioneering analysis of 200 million-year-old teeth belonging to the earliest mammals suggests they functioned like their cold-blooded counterparts – reptiles, leading less active but much longer lives. The research, led by the University of Bristol, UK and University of Helsinki, Finland, published in Nature Communications, is the first time palaeontologists have […]
October 13, 2020

Women with Inflammatory Breast Cancer Are Living Longer, But the Gap Between White and Black Patients Persists

Women with inflammatory breast cancer — a rare, highly aggressive form of the disease — are living about twice as long after diagnosis than their counterparts in the mid-to-late 1970s, according to a new University of Michigan Rogel Cancer Center study. The researchers found that from 1973-1977, patients diagnosed with inflammatory breast […]
October 13, 2020

Higher doses of vitamin D slowed progression of frailty in older mice, preclinical study shows

Lower levels of the vitamin negatively impacted balance and coordination. When it comes to vitamin D, most adults exhibit either frank deficiency, which results in clear clinical symptoms, or insufficiency, which often goes undetected. But how that insufficiency impacts physical health and the vulnerability of older adults to frailty as […]
October 13, 2020

Inhalable Treatment Enhances Lung Regeneration in Lung Fibrosis Model

In response to certain types of injury and inflammation, many organs produce tough scar tissue, a process called fibrosis, which can ultimately lead to organ failure or even death. Fibrosis is such a central component of so many different diseases – from cardiovascular disease to kidney failure – that scientists […]
October 13, 2020

Predicting the cancer-causing potential of chemicals released from wildfires, fossil fuel burning

Oregon State University scientists have developed a method that could potentially predict the cancer-causing potential of chemicals released into the air during wildfires and fossil fuel combustion. The research, which was recently published in the journal Toxicology in Vitro, was conducted as a part of the OSU Superfund Research Program.  The findings […]
October 13, 2020

Brain imaging can predict childhood weight gain

A greater density of cells in a key reward centre of the brain is associated with obesity in children and predicts future weight gain, a new Yale-led study finds. The findings, published in the Proceedings of the National Academy of Sciences, suggest that a greater concentration of specialized cells in […]
October 12, 2020

Researchers disrupt signaling pathway to treat colitis

The white blood cell TH17 helps the immune system fight infection by promoting inflammation. But it can be too much of a good thing: Excessive inflammation from TH17 overload has been tied to autoimmune disorders, such as inflammatory bowel disease (IBD) and arthritis. Researchers led by Hening Lin, professor of chemistry […]
October 12, 2020

Research offers new insights on infertility

A University of Oregon-initiated project using tiny roundworms has identified defects tied to infertility that result when too much DNA is exchanged in the formation of sperm and eggs. The fundamental research, detailed in a paper placed online in PLOS Genetics, probed what happens when too many DNA exchanges, called […]
October 12, 2020

Scientists develop new tools to study the immune system

University of Alberta chemists have developed new tools for studying the human immune system that lay the foundation for research that could improve understanding of cancer and neurodegenerative diseases such as Alzheimer’s. “Our lab studies sugar-binding receptors called Siglecs that control cells in our immune system,” explained Matthew Macauley, assistant professor […]
October 12, 2020

New discovery could help improve cancer vaccines

Cancer vaccines have shown promise in treating certain tumors, such as melanoma. But such vaccines have limitations. They often target normal proteins that may be more abundant in the tumor but also are present in healthy tissue, which can lead to off-target effects that cause autoimmune disorders and also reduce […]
October 12, 2020

A dance of histones silences transposable elements in pluripotent stem cells

A study lead by KI researcher and SciLifeLab Fellow Simon Elsässer elucidates a new flavour of heterochromatin, used by embryonic stem cells to silence ‘parasitic’ DNA-elements within the context of their highly dynamic pluripotent chromatin. The study was recently published in Nature Communications. So-called transposons are abundant DNA-elements found in […]
October 12, 2020

UCI biochip innovation combines AI and nanoparticle printing for cancer cell analysis

Electrical engineers, computer scientists and biomedical engineers at the University of California, Irvine have created a new lab-on-a-chip that can help study tumor heterogeneity to reduce resistance to cancer therapies. In a paper published in Advanced Biosystems, the researchers describe how they combined artificial intelligence, microfluidics and nanoparticle inkjet printing […]
October 12, 2020

DNA Test Identifies Genetic Causes of Severe Fetal and Newborn Illness

A new study by University of California researchers shows the promise of high-throughput DNA-sequencing technologies to improve prenatal diagnosis and pregnancy outcomes for women who have experienced an abnormal prenatal ultrasound. In the UC San Francisco-led study, scientists used a technique called exome sequencing to identify genetic diseases as the underlying […]
October 12, 2020

FDA approves new drug to treat common form of muscular dystrophy

Created using synthetic DNA, viltolarsen is an excellent example of precision medicine. A University of Alberta researcher’s past work has led to a new drug being approved for use in the United States to treat patients suffering from Duchenne muscular dystrophy (DMD). The drug, viltolarsen, was approved for use in […]
October 12, 2020

A hydrogel that could help repair damaged nerves

Injuries to peripheral nerves –– tissues that transmit bioelectrical signals from the brain to the rest of the body ­­–– often result in chronic pain, neurologic disorders, paralysis or disability. Now, researchers have developed a stretchable conductive hydrogel that could someday be used to repair these types of nerves when […]
October 9, 2020

High-throughput screening identifies molecules that reduce cellular stress

For many people, getting older can, unfortunately, mean an increased risk of illnesses, from cardiovascular disease to cancer. University of Michigan scientists are actively researching the biological underpinnings of ageing with the aim of developing interventions that could help people live longer, healthier lives. A paper in the journal Science Advances describes […]
October 9, 2020

New research unearths key to minimising some health risks associated with ageing

A study led by researchers at WIMR has, for the first time, demonstrated how CD47 – a cell surface protein – drives biological dysfunctions in the body, such as decreased circulation and poor metabolic homeostasis, both of which worsen with age. Researchers hope developing therapies that target CD47 will significantly reduce […]
October 8, 2020

Damaged DNA

All life depends upon DNA repair and replication. In every human cell the essential ability to replicate and repair genomes depends upon the coordinated actions of the genome sequence. Flaws or mistakes in repair and cell cycle regulation can lead to defects in the structure of the DNA and can […]
October 8, 2020

PRESERVING BRAIN TISSUE WITH STEM CELLS

Individuals with traumatic brain injuries, or TBIs, frequently experience the shrinking or atrophying of brain tissue near where the injury occurred, causing additional damage beyond the original harm. If this can be prevented, many could function in the future who cannot now. Few therapies currently exist to treat TBIs, but […]