Related Science News – Page 9 – Innovita Research

Related Science News

May 12, 2020

First roadmap of human skeletal muscle development created by UCLA scientists

Findings could lead to better methods for creating muscle cells from stem cells. An interdisciplinary team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA has developed a first-of-its-kind roadmap of how human skeletal muscle develops, including the formation of muscle […]
May 11, 2020

Stem cells shown to delay their own death to aid healing

Already known for their shape-shifting abilities, stem cells can now add “death-defying” to their list of remarkable qualities. A new study shows how stem cells – which can contribute to creating many parts of the body, not just one organ or body part – are able to postpone their own […]
May 11, 2020

Unexpectedly potent protein droplets

Repeats of individual building blocks within proteins are the cause of many hereditary diseases, but how such repeats actually cause disease is still largely unknown. Researchers in Berlin investigated how repeat elongations lead to the disease synpolydactyly, and have found that the attractive forces between the mutated proteins cause them […]
May 11, 2020

Exercise Boosts Motor Skill Learning Via Changes in Brain’s Transmitters

Doctors have relentlessly impressed upon us the many benefits of exercise. Energy, mood, sleep and motor skills all improve with a regular fitness regimen that includes activities such as running. This has become of particular interest in the time of the COVID-19 pandemic. But what happens in the brain during […]
May 11, 2020

Nanostimulators boost stem cells for muscle repair

In regenerative medicine, an ideal treatment for patients whose muscles are damaged from lack of oxygen would be to invigorate them with an injection of their own stem cells. In a new study published in the journal ACS Nano, researchers at the University of Illinois at Urbana-Champaign demonstrated that “nanostimulators” […]
May 11, 2020

Molecule reduces multiple pathologies associated with Alzheimer’s disease

When tested in brain cells and in a mouse model of Alzheimer’s disease, a new compound significantly reduced the number of amyloid plaques in the brain, lessened brain inflammation and diminished other molecular markers of the disease. The researchers who developed the compound reported their findings in the journal ACS […]
May 11, 2020

Game-changing blood test accurately detects Alzheimer’s disease

A simple blood test that can detect Alzheimer’s disease (AD) has been discovered and validated in a joint effort by a McGill team and researchers in Sweden. Their results are published in the May issue of The Lancet Neurology. An accompanying commentary calls the discovery “transformative.” The blood test accurately measures one of the […]
May 11, 2020

NSF provides support for drug discovery platform for hard-to-treat cancers

A new round of support will help a Purdue University-affiliated startup further develop a platform designed to create drugs for people with hard-to-treat cancers. Akanocure Pharmaceuticals, Inc., has received Small Business Innovation Research Phase II funding from America's Seed Fund, powered by the National Science Foundation, to develop chemical tools and platforms to produce valuable […]
May 8, 2020

Newly discovered mechanism can explain increased risk of dementia

Millions of people around the world use acid suppressants called proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. Researchers at Karolinska Institutet in Sweden now report how the long-term use of these drugs could increase the risk of developing dementia. Their results are published in the journal […]
May 8, 2020

More Selective Elimination of Leukemia Stem Cells and Blood Stem Cells

Hematopoietic stem cells from a healthy donor can help patients suffering from acute leukemia. However, the side effects of therapies are often severe. A group of researchers led by the University of Zurich have now shown how human healthy and cancerous hematopoietic stem cells can be more selectively eliminated using […]
May 7, 2020

Another Example of a Galactose-Conjugated Senolytic Prodrug

Killing cells is easy. Killing only the cells that you want to kill, while leaving all other cells untouched, is very much more challenging. The ability to do this is fundamental to much of the future of medicine, however. The aging body contains many cell populations that cause significant harm […]
May 7, 2020

Towards Ionomic Aging Clocks

The ionome is the elemental composition of a tissue, organ, or individual. This composition changes over the course of aging, and may do so in ways that allow the production of an aging clock, a measure of chronological or physiological age. This line of development adds to work on the well-known epigenetic clocks, proteomic […]
May 7, 2020

New Frontiers in Cardiovascular Research: Stefania Nicoli, PhD

For over a decade, Stefania Nicoli, PhD, has used zebrafish to study disease. The remarkable similarities between humans and these tiny freshwater fish provide valuable information about the genetic root of human disease. The Nicoli lab investigates how microRNAs (miRNAs) play a role in the physiology of the cardiovascular system. The lab […]
May 7, 2020

Focused ultrasound opening brain to previously impossible treatments

University of Virginia researchers are pioneering the use of focused ultrasound to defy the brain’s protective barrier so that doctors could, at last, deliver many treatments directly into the brain to battle neurological diseases. The approach, the researchers hope, could revolutionize treatment for conditions from Alzheimer’s to epilepsy to brain […]
May 7, 2020

Treatment for prostate cancer could protect men from COVID-19

Men are more susceptible to COVID-19. However, those who have cancer are even more vulnerable as they face a 1.8-​fold increased risk of COVID-​19 infection compared to the whole male population. Men with cancer also develop more severe symptoms and are harder to treat. However, a new study at the […]
May 7, 2020

Resilience to ALS Due to Synaptic Safety Mechanism

A common feature of neurodegenerative diseases such as Alzheimer’s disease and amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) is the progressive loss of synapses – the anatomical sites of communication between brain cells – throughout the brain and spinal cord. Typically, synapse loss becomes pervasive before the outward appearance […]
May 7, 2020

Brain study contributes to increased understanding of endocrine diseases

Many nerve cells in the brain region hypothalamus have unexpected origins and go through complex development programs, where millions of neurons assemble into a precisely knit network by birth. That is according to a study by researchers at Karolinska Institutet in Sweden and the Medical University of Vienna published in […]
May 7, 2020

Possible vaccine for virus linked to type 1 diabetes

According to many observations, certain virus infections may play a part in the autoimmune attack that leads to type 1 diabetes. Researchers at Karolinska Institutet in Sweden and their Finnish colleagues have now produced a vaccine for these viruses in the hope that it could provide protection against the disease. […]
May 7, 2020

U of T researchers use diphtheria toxin to target genes in cancer cells

A group of researchers from the University of Toronto and the Hospital for Sick Children have developed a new way to deliver molecules that target specific genes within cells. The platform, which uses a modified form of diphtheria toxin, has been shown to “downregulate” critical genes in cancer cells, and could be […]
May 6, 2020

Scientists have a hypothesis, why COVID-19 affects older people more

Both old and young people can get COVID-19. However, healthy young people usually get better without any treatment at all, while older patients can experience some life-threatening complications. Why older people are at higher risk of more difficult COVID-19 cases? Scientists from ETH Zurich have a good hypothesis. As you […]
May 6, 2020

Therapy Harnesses Immune System to Slow Progression of DIPG Brain Tumors

Researchers are learning more about how to harness the immune system to find new treatment options for deadly brain cancer that strikes young children. Diffuse intrinsic pontine glioma, or DIPG, tumors can’t be surgically removed due to their location on a critical structure of the brain called the brain stem. […]
May 6, 2020

MRI technique could reduce need for radiation in measuring tumor response to chemotherapy

Whole body diffusion-weighted magnetic resonance imaging (DW MRI) may aid in the assessment of cancer treatment response in children and youth at much lower levels of radiation than current approaches, suggests a small study funded by the National Institutes of Health. The results appear in Radiology. Researchers compared DW MRI, which […]
May 6, 2020

Electrical Activity in Living Organisms Mirrors Electrical Fields in Atmosphere

Most electrical activity in vertebrates and invertebrates occurs at extremely low frequencies, and the origin — and medical potential — of these frequencies have eluded scientists. Now a Tel Aviv University study provides evidence for a direct link between electrical fields in the atmosphere and those found in living organisms, including humans. […]
May 6, 2020

UB investigators uncover cellular mechanism involved in Krabbe disease

A group of researchers at the University at Buffalo have published a paper that clarifies certain cellular mechanisms that could lead to improved outcomes in patients with globoid cell leukodystrophy, commonly known as Krabbe disease. The paper, titled “Macrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of […]
May 5, 2020

Overlapping versions of our entire genetic history, present in every cell, complicate the delivery of precision medicine

The massive international effort to map the entire human genome, completed in 2003, opened a new field we now know as personalized medicine. The breakthrough, which identified the location and function of every human gene, offered the promise of medical care tailored specifically to individual patients, based on their personal […]
May 5, 2020

Combining mouse and human data uncovers new gene regulating cholesterol

Precision medicine has the potential to tailor treatments to a patient’s unique genetic sequence. But achieving this precision — or developing new drugs — requires knowing which genes are involved in the disease. “Unfortunately, we don’t really have a good understanding of how these genetic differences can derive differences in […]
May 5, 2020

Obesity prevented in mice treated with gene-disabling nanoparticles

Disabling a gene in specific mouse cells, researchers at Washington University School of Medicine in St. Louis have prevented mice from becoming obese, even after the animals had been fed a high-fat diet. The researchers blocked the activity of a gene in immune cells. Because these immune cells — called […]
May 5, 2020

Heart Trouble

Since the World Health Organization declared COVID-19 a public health concern of global interest on Jan. 30, more than one million have tested positive for the illness in the United States and more than 62,000 have died. With no FDA–approved treatments available to date, the antimalarial drug hydroxychloroquine has emerged as […]
May 5, 2020

Understanding Congenital Heart Defects, One Chicken at a Time

Approximately 10 percent of infants are born with a congenital heart defect, with one of the most common being persistent truncus arteriosus—a hole in the heart. In a healthy baby, deoxygenated blood is pumped through a one-way blood vessel to the lungs, where it becomes oxygenated and is pumped through […]
May 5, 2020

Study to examine how sleep during lockdown affects older people with or without dementia

It has long been known that disrupted sleep can increase the risk of dementia and anecdotal evidence suggests COVID-19 anxiety is having a detrimental effect on sleep. A new UK-wide study led by academics at the University of Bristol will focus on how the current lockdown is affecting sleep in […]