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Recently, neurobiologists from Leipzig and Würzburg universities investigated that a gene mutation that causes blindness is also associated with increased verbal IQ and working memory. Thus far, it was unclear how the mutation affects synaptic function. Scientists used CRISPR/Cas9-assisted genomic engineering to insert patients’ mutations into the corresponding gene in […]

In patients with familial adenomatous polyposis, a genetic disease predisposing to colon cancer, mutations of the APC gene induce the formation of intestinal polyps, but also reduce immune system activity. In a new study, researchers from the Institut Pasteur, INSERM(1) and Université Paris Cité describe the mechanisms that modify the […]