Related Science News – Page 128 – Innovita Research

Related Science News

April 17, 2021

New type of cell contributes to increased understanding of ALS

The causes of the serious muscle disease ALS still remain unknown. Now, researchers at Karolinska Institutet and KTH Royal Institute of Technology, among others, have examined a type of cell in the brain blood vessels that could explain the unpredictable disease origins and dynamics. The results indicate a hitherto unknown […]
April 16, 2021

7.2% of All Deaths Worldwide are Attributable to Physical Inactivity

Humans evolved in an environment of physical exertion, and our biochemistry requires physical exertion in order to trigger mechanisms of cell maintenance and metabolic regulation. Populations that exercise vigorously into late old age, such as the Tsimane in Bolivia, exhibit very much lower levels of cardiovascular disease. Further, living a […]
April 16, 2021

UO discovery could one day help rejuvenate the adult brain

Imagine a drug that could temporarily reenergize plasticity in the brain to treat autism or schizophrenia, or even help an adult’s ageing brain pick up a new language or learn to play a musical instrument. Such are the potential, down-the-road medical implications of a discovery made by a postdoctoral researcher […]
April 16, 2021

CD40 Drug Before Surgery Shows Promise in Early-stage Pancreatic Cancer

Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments, according to a new study from researchers in the Abramson Cancer Center (ACC) at the University of Pennsylvania. Changing the microenvironment from so-called T cell […]
April 16, 2021

Power of light and oxygen clears Alzheimer’s disease protein in live mice

A small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the brains of Alzheimer’s disease patients. If perfected in humans, the technique could be used as an alternative approach to immunotherapy and used to treat other diseases caused by similar […]
April 16, 2021

TAU researchers achieve breakthrough in battle against brain cancer

Groundbreaking research from Tel Aviv University may lead to a significant breakthrough in the battle against deadly brain cancer. TAU researchers have identified a failure in the brain’s immune system that leads to the amplification of cell division and the spread of glioblastoma cancer cells. The failure results partially from the secretion […]
April 16, 2021

Biomarker Could Help Identify Difficult-to-Diagnose Kidney Cancer Subtype

High expression levels of the gene TRIM63 can serve as an accurate and sensitive biomarker of a subtype of kidney cancer known as microphthalmia-associated transcription factor family aberration-associated renal cell carcinomas — or MiTF renal cell carcinoma. That’s according to a new, multi-institution study led by researchers at the University of Michigan Center for Translational […]
April 16, 2021

Does Public Policy Affect Alcohol-Related Liver Disease Deaths?

Alcohol-related liver disease is on the rise in the United States. Most strikingly, this epidemic is disproportionally affecting young, otherwise healthy, people, leading to rapid increases in alcohol-related liver disease deaths. “Changes in mortality rates for the alcohol-related liver disease vary significantly from state to state, so we think socioeconomic […]
April 16, 2021

Increased risk of liver cancer in patients with non-alcoholic fatty liver

Non-alcoholic fatty liver disease, NAFLD, is associated with several health risks. According to a new registry study led by researchers at Karolinska Institutet in Sweden, NAFLD is linked to a 17-fold increased risk of liver cancer. The findings, published in Hepatology, underscore the need for improved follow-up of NAFLD patients […]
April 15, 2021

Methionine Restriction Greatly Reduces Measures of Cognitive Decline in Mice

Researchers here applied three months of a methionine restricted diet to old mice, and found that it greatly reduced age-related cognitive decline, as measured in maze tests. The methionine restricted animals perform more like young animals than like their unrestricted peers. Methionine is an essential amino acid essential to all […]
April 15, 2021

New Obesity Tool?

A new source of energy expending brown fat cells has been uncovered by Harvard Medical School researchers at Joslin Diabetes Center, which they said points towards potential new therapeutic options for obesity. According to the new report, published in Nature Metabolism, the key lies in the expression of a receptor […]
April 15, 2021

With a health equity lens, study focuses on diabetes-related vision loss

The University of Toronto’s Aleksandra Stanimirovic is currently leading a study that, she says, underscores the reason she chose to become a health researcher as opposed to a physician. The project focuses on a screening program for diabetic retinopathy – a complication of diabetes that can lead to blindness – among women from lower socio-economic groups. She […]
April 15, 2021

Inflammation a key to targeting pregnancy-associated breast cancer

Targeting the tumour environment may help improve treatments for breast cancers affecting pregnant women and young mothers. New research led by the Garvan Institute of Medical Research has revealed how breast cancer cells that develop during or after pregnancy change their environment to form more aggressive tumours. In experimental models […]
April 15, 2021

How antibodies make the switch to better immunity

Researchers have uncovered how antibodies that are specialised to different immune ‘disposal systems’ become the dominant form in the bloodstream, a process that is critical to our immune system’s ability to destroy pathogens and a key objective for the development of effective vaccines. Findings led by the Garvan Institute of […]
April 15, 2021

Altered immune signature linked to Long-Covid

University of Manchester scientists have discovered a persistent alteration in the immune system of patients, six months after they have been hospitalised for Covid-19, which could be associated with poorer health outcomes. The study, published in the journal Med, examines the impact of a SARS-CoV-2 infection on the immune system of […]
April 14, 2021

PPARα Slows Atherosclerosis by Inhibiting Vascular Cellular Senescence

It may turn out to be the case that many mechanisms of cellular regulation that slow aspects of aging function, at least in part, by slowing the pace at which senescent cells accumulate. Senescent cells induce tissue dysfunction via inflammatory signaling. Studies in which senescent cells are selectively destroyed in […]
April 14, 2021

Cancer DNA blood tests validated by international research team

An international team today reports the findings of an independent assessment of five commercially available assays for tumour DNA sequencing – a fast, cheap and less invasive method to diagnose and monitor cancer. The researchers revealed that all assays could reliably detect so-called circulating tumour DNA (ctDNA) when it made […]
April 14, 2021

Patients with Metastatic Breast Cancer and High Mutational Burden Benefit from Pembrolizumab

The immunotherapy agent pembrolizumab can provide clinical benefit to some patients with metastatic breast cancer whose tumors were found to have a high number of mutations, and whose cancer continued to progress with standard treatments. That’s according to newly published results from ASCO’s Targeted Agent and Profiling Utilization Registry (TAPUR) study. […]
April 14, 2021

Drug testing approach uncovers effective combination for treating small cell lung cancer

Researchers from the National Institutes of Health have identified and tested a drug combination that exploits a weakness in small cell lung cancer (SCLC), an aggressive, dangerous cancer. The scientists targeted a vulnerability in how the cancer cells reproduce, increasing already high levels of replication stress ­­– a hallmark of […]
April 14, 2021

U of A research could help diagnose prostate cancer severity more accurately

Scientists at the University of Alberta are part of a new research project to develop innovative precision diagnostics that could predict which men with prostate cancer are at risk of developing an aggressive form of the disease. The researchers will use germline sequencing (sequencing of the genes a person is […]
April 13, 2021

GlyNAC improves strength and cognition in older humans

A pilot human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC – a combination of glycine and N-acetylcysteine as precursors of the natural antioxidant glutathione – could improve many age-associated defects in older humans to improve muscle strength and cognition, and promote healthy […]
April 13, 2021

New research on good cholesterol possibly finds better marker for cardiovascular disease

Good cholesterol, which is transported in HDLs (high-density lipoproteins), plays a key part in the prevention of atherosclerosis and thus the risk of cardiovascular disease. However, according to a new paper co-authored by researchers at Karolinska Institutet and published in the journal Circulation, the anti-inflammatory properties of HDLs could be […]
April 13, 2021

Technique allows mapping of epigenetic information in single cells at scale

Histones are tiny proteins that bind to DNA and hold information that can help turn on or off individual genes. Researchers at Karolinska Institutet have developed a technique that makes it possible to examine how different versions of histones bind to the genome in tens of thousands of individual cells […]
April 13, 2021

Living Foams

Researchers uncover how cells control the physical state of embryonic tissues. In the earliest stage of life, animals undergo some of their most spectacular physical transformations. Once merely blobs of dividing cells, they begin to rearrange themselves into their more characteristic forms, be they fish, birds or humans. Understanding how […]
April 12, 2021

COVID-19 transmission from mother to fetus confirmed by proteomics

Researchers from Skoltech were part of a research consortium studying a case of vertical COVID-19 transmission from mother to her unborn child that resulted in major complications in the pregnancy, premature birth and death of the child. The consortium used a Skoltech-developed proteomics method to verify the diagnosis. The paper […]
April 12, 2021

Case Western Reserve awarded $3 million National Cancer Institute grant to apply AI to immunotherapy in lung cancer patients

Medical researchers from Case Western Reserve University, New York University (NYU), and University Hospitals have been awarded a five-year, $3 million National Cancer Institute grant to develop and apply artificial intelligence (AI) tools for predicting which lung cancer patients will respond to immunotherapy. A unique aspect of the Case Western […]
April 12, 2021

Leaking calcium in neurons an early sign of Alzheimer’s pathology

Alzheimer’s disease is known for its slow attack on neurons crucial to memory and cognition.  But why are these particular neurons in ageing brains so susceptible to the disease’s ravages, while others remain resilient? In a new study published in the journal Alzheimer’s & Dementia, The Journal of the Alzheimer’s […]
April 12, 2021

How to tame a restless genome

Short pieces of DNA—jumping genes—can bounce from one place to another in our genomes. When too many DNA fragments move around, cancer, infertility, and other problems can arise. Cold Spring Harbor Laboratory (CSHL) Professor & HHMI Investigator Leemor Joshua-Tor and a research investigator in her lab, Jonathan Ipsaro, study how cells safeguard […]