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The protein actin is ubiquitous and essential for life. In mammals, every cell expresses two of its forms, beta-actin and gamma-nonmuscle-actin. Despite having distinct roles, the two forms are nearly identical, sharing 99% of their amino acid sequence. Research by Anna Kashina of Penn’s School of Veterinary Medicine and colleagues has shown that, […]

Studying drug effects on human muscles just got easier thanks to a new “muscle-on-a-chip,” developed by a team of researchers from Penn’s School of Engineering and Applied Science and Inha University in Incheon, Korea. Muscle tissue is essential to almost all of the body’s organs, however, diseases such as cancer and diabetes […]

Researchers discovered that a large amount of enterobacteria in the gut microbiota is related to long-term mortality risk in Finnish adult population. The study conducted by the University of Turku and the Finnish Institute for Health and Welfare together with an international research team is so far the largest population-level […]

Researchers at the University of Turku, Finland, showed that the antibody treatment reactivates the immune defense in patients with advanced-stage cancer. The treatment alters the function of the body’s phagocytes and facilitates extensive activation of the immune system. The immune defense is the body’s own defense system equipped to combat […]

Significant amounts of atherosclerotic plaque have been found in the coronary arteries of people with HIV, even in those considered by traditional measures to be at low-to-moderate risk of future heart disease, according to a study published in JAMA Network Open. This finding emerged from the global REPRIEVE (Randomized Trial to […]

Aspirin can reduce the risk of serious cardiovascular events such as ischemic stroke and heart attack in patients with pneumonia, according to new research. Serious cardiovascular complications are common in cases of pneumonia and are strongly associated with long-term mortality. A study by Dr Fergus Hamilton and colleagues at the University of Bristol looked […]

A new study has pinpointed a small group of cells in the brain which could be crucial to understanding how Alzheimer’s disease begins and how to slow its progression. This discovery could help research into treatment for the disease by focusing on this key group of cells in the brain. […]

Ultrasound can overcome some of the detrimental effects of ageing and dementia without the need to cross the blood-brain barrier, researchers at The University of Queensland have found. Professor Jürgen Götz from UQ’s Queensland Brain Institute (QBI) led a multidisciplinary team who showed low-intensity ultrasound effectively restored cognition without opening the barrier in mice models. The findings […]

Saturated fatty acid levels unexpectedly rise in the brain during memory formation, according to University of Queensland research, opening a new avenue of investigation into how memories are made. Dr Tristan Wallis, from Professor Frederic Meunier’s laboratory at UQ’s Queensland Brain Institute (QBI), said traditionally, polyunsaturated fatty acids were considered important to health and […]

A genetic map of an aggressive childhood brain tumour called medulloblastoma has helped researchers identify a new generation anti-cancer drug that can be repurposed as an effective treatment for the disease. This international collaboration, led by researchers from The University of Queensland’s Diamantina Institute and WEHI in Melbourne, could give parents hope in the fight […]

Researchers from the Turku PET Centre and Technical University of Munich have discovered a new mechanism controlling satiation. According to the recently published study, the hormone secretin induces satiation by activating brown adipose tissue. Brown adipose tissue is known for its ability to generate heat in response to cold exposure. […]

The LSL60101 compound, a specific ligand of the I2-IR receptors in the brain, could shed light on the development of future strategies against Alzheimer's disease. This is stated in the recent studies by the Research Group on Medicinal Chemistry and Pharmacology of Neurodegenerative Diseases of the University of Barcelona, published […]

After receiving a COVID-19 vaccine, many experience mild yet common symptoms, such as headache, fatigue and muscle pain – side effects reported by more than 100,000 Australians to date in a national survey. These vaccine side effects have led to hesitancy in some younger people, who may have more symptoms following a […]

Adults with ADHD are at higher risk of a wide range of physical conditions, including nervous system, respiratory, musculoskeletal, and metabolic diseases, according to a large register-based study from Karolinska Institutet published in The Lancet Psychiatry. “Identifying co-occurring physical diseases may have important implications for treating adults with ADHD and […]

Research ID's immune cells that sculpt inhibitory neurons, regulate brain wiring. From the bark of a puppy to the patter of rain against the window, our brains receive countless signals every second. Most of the time, we tune out inconsequential cues—the buzz of a fly, the soft rustle of leaves […]

A transplant of healthy gut microbes followed by fibre supplements benefits patients with severe obesity and metabolic syndrome, according to University of Alberta clinical trial findings published in Nature Medicine. Patients who were given a single-dose oral faecal microbial transplant followed by a daily fibre supplement were found to have better […]

The COVID vaccines currently being deployed were developed with unprecedented speed, but the mRNA technology at work in some of them is an equally impressive success story. Because any desired mRNA sequence can be synthesized in massive quantities, one of the biggest hurdles in a variety of mRNA therapies is […]

Patients who had their wisdom teeth extracted had improved tasting abilities decades after having the surgery, a new Penn Medicine study published in the journal Chemical Senses found. The findings challenge the notion that removal of wisdom teeth, known as third molars, only has the potential for negative effects on taste, and represent one of […]

Our cells have abilities that go far beyond the fastest, smartest computer. They generate mechanical forces to propel themselves around the body and sense their local surroundings through a myriad of channels, constantly recalibrating their actions. The idea of using cells as medicine emerged with bone marrow transplants, and then […]

Researchers studying COVID-19 patients have found a metabolic pathway that is highly correlated with immune responses only in male patients, a group known to be more likely to suffer severe cases and die of the disease, representing a potential target for therapeutic intervention. In a study published in the journal […]

In the future, it could be possible to stimulate the immune system with extremely high efficacy via the skin. Cutanos GmbH, a spin-off from the Max Planck Institute of Colloids and Interfaces, has developed a corresponding method for modulating immune cells in the skin. The LC-TDS technology makes it possible […]

University of California San Diego School of Medicine researchers have identified a possible link between inadequate exposure to ultraviolet-B (UVB) light from the sun and an increased risk of colorectal cancer, especially as people age. Reporting in the journal BMC Public Health, researchers investigated global associations between levels of UVB light […]

Researchers from Ernst Federal Science Center for Animal Husbandry, Skoltech, Moscow State University and their colleagues have produced the first viable cloned calf in Russia – and she recently turned one. In a related experiment, the team was able to knock out the genes responsible for beta-lactoglobulin, a protein causing […]

Researchers from Skoltech and the Mental Health Research Center have found 22 lipids in the blood plasma of people with schizophrenia that were associated with lower symptom improvement over time during treatment. These can help track resistance to medication that affects over a third of patients. The paper was published in the journal Biomolecules. […]

Mayo Clinic researchers are taking a close look at rare cases of inflammation of the heart muscle, or myocarditis, in young men who developed symptoms shortly after receiving the second dose of the Moderna or Pfizer messenger RNA (mRNA) COVID-19 vaccines. Several recent studies suggest that health care professionals should watch for hypersensitivity […]

Researchers at Karolinska Institutet publish new findings in the journal Cancer Discovery showing how pharmacological activation of the protein p53 boosts the immune response against tumours. The results can be of significance to the development of new combination therapies that will give more cancer patients access to immunotherapy. Given its […]

In 2017, Green Bay Packers quarterback Aaron Rodgers broke his right collarbone in a game against the Minnesota Vikings. Typically, it takes about 12 weeks for a collarbone to fully heal, but by mid-December fans and commentators were hoping the three-time MVP might recover early and save a losing season. […]

Studies reveal unprecedented mechanism behind loss of antibody neutralization against this pandemic coronavirus variant of concern. Three mutations in the Epsilon coronavirus Spike protein dampen the neutralizing potency of antibodies induced by current vaccines or past COVID infections. The mutations give this coronavirus variant of concern a means to totally […]

Flies have discriminating taste. Like a gourmet perusing a menu, they spend much of their time seeking sweet nutritious calories and avoiding bitter, potentially toxic food. But what happens in their brains when they make these food choices? Yale researchers discovered an interesting way to find out. They tricked them. […]

Using Argonne National Laboratory’s Advanced Photon Source, researchers have determined the structure of an enzyme that plays a key role in the spread of cancer cells. Chances are, every one of us has been affected by cancer in one way or another. Unlike some other deadly diseases, cancer can take […]