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Fisetin is perhaps the most intriguing of the first generation senolytic compounds, those capable of selectively destroying senescent cells in old tissues and thus producing rejuvenation to a meaningful degree. Senolytics have been demonstrated in animal studies to reverse many age-related conditions to a greater degree than any other approaches. […]

Imagine going to a surgeon to have a diseased or injured organ switched out for a fully functional, laboratory-grown replacement. This remains science fiction and not reality because researchers today struggle to organize cells into the complex 3D arrangements that our bodies can master on their own. There are two […]

A scientific study carried out by the Universidad Carlos III de Madrid (UC3M) and the Universidad Complutense de Madrid (UCM) has produced a mathematical description of the way in which a tumour invades the epithelial cells and automatically quantifies the progression of the tumour and the remaining cell islands after […]

Human genes have an impact on shaping our gut ecosystem according to new evidence from the international MIBioGen consortium study involving more than 18,000 people. The findings, led by the University Medical Center Groningen, Netherlands and involving researchers at the University of Bristol, are published today [18 January] in Nature […]

As the number of people who have fought off SARS-CoV-2 climbs ever higher, a critical question has grown in importance: How long will their immunity to the novel coronavirus last? A new Rockefeller study offers an encouraging answer, suggesting that those who recover from COVID-19 are protected against the virus […]

Targeted neuromodulation tailored to individual patients’ distinctive symptoms is an increasingly common way of correcting misfiring brain circuits in people with epilepsy or Parkinson’s disease. Now, scientists at UC San Francisco’s Dolby Family Center for Mood Disorders and Weill Institute for Neurosciences have demonstrated a novel personalized neuromodulation approach that – at least in […]

Anyone who has tried and failed to meditate knows that our minds are rarely still. But where do they roam? New research led by UC Berkeley has come up with a way to track the flow of our internal thought processes and signal whether our minds are focused, fixated or […]

Today's open access research paper is a reminder of one of the more direct mechanistic links between vascular aging and brain aging. Blood vessels stiffen with age, becoming progressively worse at the necessary task of contracting and relaxing in response to circumstances. This is in part due to cross-linking in […]

In addition to a skin rash, many eczema sufferers also experience chronic itching, but sometimes that itching can become torturous. Worse, antihistamines — the standard treatment for itching and allergy — often don’t help. New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often […]

Waldenström macroglobulinemia (WM), a rare form of lymphoma, does not have any known cure and only one FDA-approved treatment making it challenging to treat patients. Researchers at the University of New Hampshire took the novel approach of targeting specific cell proteins that control DNA information using inhibitors, or drugs, that […]

There is far too much incrementalism in the present research and development of therapies to treat aging. Much of the field is engaged in mimicking calorie restriction or repurposing existing drugs that were found to increase mouse life span by a few percentage points. This will not meaningfully change the […]

In the 1920s, German chemist Otto Warburg discovered that cancer cells don’t metabolize sugar the same way that healthy cells usually do. Since then, scientists have tried to figure out why cancer cells use this alternative pathway, which is much less efficient. MIT biologists have now found a possible answer […]

Researchers at the Center for Computational Imaging and Personalized Diagnostics (CCIPD) at Case Western Reserve University have preliminarily validated an artificial intelligence (AI) tool to predict how likely the disease is to recur following surgical treatment for prostate cancer. The tool, called RadClip, uses AI algorithms to examine a variety of data, […]

Haruhiko Morita had never aspired to be an entrepreneur, but his astute foresight was instrumental in landing his current position of a chief executive officer at Modalis Therapeutics Corp. In the late 1980s and early 1990s, while Morita was an undergraduate and graduate student at the Faculty of Engineering and […]

Frailty is usually accompanied by greater immune dysfunction, given that chronic inflammation is a strong component of both immune aging and the various dysfunctions of frailty. Thus frail individuals exhibit a worse response to vaccinations intended to prevent infectious disease. This is unfortunate, as this is the population in greatest […]

Chronic back pain can keep us from living our best lives, but a University of Alberta study shows why some people don’t let it stop them. The research, published in the Journal of Occupational Rehabilitation, sheds light on what motivates people to soldier through their persistent pain. The qualitative study is one […]

New tool reveals details about motor neuron circuitry in fruit flies. How do networks of neurons connect to form functional circuits? To address this long-standing question in neuroscience, researchers from Boston Children's Hospital and Harvard Medical School have developed a new pipeline to study neural circuits and, in the process, […]

Dopamine is one of the essential neurotransmitters in the brain. Its action is limited to the brain; it acts as a chemical messenger throughout the body. Dopamine stimulates the cardiovascular system's work and is responsible for cognitive abilities, coordination of movements, and even feelings. Here, we will try to explain […]

Cancer is a notoriously complex disease, in part because it may be caused by mutations among hundreds or even thousands of genes. In addition, most cancers exhibit an extraordinary amount of variation among genetic mutations, even between patients with the same types of cancers. Consequently, cancer researchers have chosen to […]

pandemics and epidemics, public health officials must identify individuals who are actively infected or have previously been infected, both to control the spread of disease and, in the case of vaccine-preventable illnesses, to prioritize individuals for vaccination. The SARS-CoV-2 pandemic has shone a bright light on the crucial need for […]

Researchers have developed a blood test that could make it possible for doctors to detect — then quickly prevent or slow down — acute heart transplant rejection, a potentially deadly condition that occurs in the early months after a patient has received a donor heart. They estimate that the test […]

For many years, researchers at the National Food Institute, Technical University of Denmark have studied the harmful effects of chemicals and developed methods to best and most effectively investigate their harmful effects. Of the many thousands of chemical substances to which humans can be exposed, the majority has not been […]

Resilience, meaning the ability to recover from wounds, infection, and other forms of damage, is more or less the flip side of frailty in aging. Frailty increases, resilience decreases. A damaged system is less robustly resilient to further damage, as reliability theory tells us. Degenerative aging is precisely an accumulation […]

The body’s immune system is the first line of defence against infections like bacteria, viruses or cancers. Some cancers, however, have developed the art of molecular deception to avoid destruction by the body’s immune system. However, a University of Missouri researcher might have found a new way to help the […]

When kidneys are removed from deceased organ donors in the United States, they are often subjected to “procurement biopsies” and are discarded if certain abnormalities are seen in the kidney tissue — a practice that worsens the already-severe shortage of transplant-eligible kidneys in the country. However, a large portion of […]

The use of cannabidiol (CBD), the major non-psychoactive compound in cannabis, is on the rise across the United States. Pregnant women, in particular, may view CBD as more “natural” than other remedies for concerns such as nausea and pain, but the consequences of use for the developing fetus are unknown. […]

Exercise is known to improve health and extend the healthy portion of life span, but not extend life span itself in mice. This is a much lesser effect than that of calorie restriction, which does extend maximum life span in addition to improving health. From a very high level view, […]

Cancer is one of the world’s greatest health afflictions because, unlike some diseases, it is a moving target, constantly evolving to evade and resist treatment. In a paper published in an online issue of Nature, researchers at University of California San Diego School of Medicine and the UC San Diego […]

Touted by makers as a “healthy” alternative to traditional nicotine cigarettes, new research indicates the chemicals found in e-cigarettes disrupt the gut barrier and trigger inflammation in the body, potentially leading to a variety of health concerns. In the study, published in the journal iScience, Soumita Das, PhD, associate professor […]

Researchers at University of California San Diego School of Medicine, in collaboration with Dutch scientists, have found that certain metabolites — small molecules produced by the process of metabolism — may be predictive indicators for persons at risk for recurrent major depressive disorder. The findings were published in an online […]