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NineSigma, representing a Japanese pharmaceutical company with an expertise in bone-related diseases as one of their future focal areas, seeks a potential collaboration partner(s) that possess drug discovery seeds or molecular targets for rare diseases involving bones and growth plate cartilage. Through collaboration with a potential partner(s), the client ultimately aims to […]

By applying unsupervised and automated machine learning techniques to the analysis of millions of cancer cells, Rebecca Ihrie and Jonathan Irish, both associate professors of cell and developmental biology, have identified new cancer cell types in brain tumors. Machine learning is a series of computer algorithms that can identify patterns within enormous quantities […]

National Institutes of Health investigators and colleagues have discovered that when the immune system first responds to infectious agents such as viruses or bacteria, a natural brake on the response prevents overactivation. Their new study in mBio describes this brake and the way pathogens such as SARS-CoV-2, the virus that causes […]

Princeton researchers have created a device that can herd groups of cells like sheep, precisely directing the cells’ movements by manipulating electric fields to mimic those found in the body during healing. The technique opens new possibilities for tissue engineering, including approaches to promote wound healing, repair blood vessels, or […]

The role genetics and gut bacteria play in human health has long been a fruitful source of scientific enquiry, but new research marks a significant step forward in unraveling this complex relationship. Its findings could transform our understanding and treatment of all manner of common diseases, including obesity, irritable bowel […]

In a study in mice, researchers at Karolinska Institutet have discovered a new potential therapeutic approach to facilitate neurological recovery in people with diabetes suffering from a stroke. The treatment strategy is based on the chronic normalization of hyperglycemia after stroke. The scientists hope that these new results, presented in […]

As COVID-19 restrictions loosen this summer, Canadians will spend more time outdoors and make the most of the sunshine. A new study from McGill University suggests why men may be more genetically prone to develop skin cancer. The research led by Professor Ian Watson of McGill’s Goodman Cancer Research Centre […]

An international research team led by Dr. Tali Ilovitsh of the Biomedical Engineering Department at TAU developed a noninvasive technology platform for gene delivery into breast cancer cells. The technique combines ultrasound with tumor-targeted microbubbles. Once the ultrasound is activated, the microbubbles explode like smart and targeted warheads, creating holes in cancer cells' […]

The expansion of the human brain during evolution, specifically of the neocortex, is linked to our cognitive abilities such as reasoning and language. Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden have been studying a gene called ARHGAP11B for many years. This gene […]

A new method of analysing cancer patients’ blood for evidence of the disease could be up to ten times more sensitive than previous methods according to new research led by the University of Cambridge. In the coming years, this method and others based on this approach could lead to tests […]

Chemical engineers from the USC Viterbi School of Engineering have unlocked a fatal vulnerability in many cancer cells—sugar inflexibility. Like any cells in the body, cancer cells need sugar ­– namely glucose – to fuel cell proliferation and growth. Cancer cells in particular metabolize glucose at a much higher rate […]

New images of an enzyme in action as it interacts with the chromosome could provide important insight into how cells — including cancer cells — regulate their genes. The enzyme, LSD1, can “turn off” gene expression by removing chemical flags (methyl groups) from the nucleosome — tightly packed units of […]

One woman shares her experience with the Ross procedure, an aortic valve replacement surgery performed by only a few cardiac surgeons in the country. As a teacher at Madonna University in Livonia, Michigan, Anne McLeod, R.N., D.N.P., was able to let her nursing students hear the sound of a heart […]

A major U.S. study reveals large gaps between urban and rural patients in quality of care received after a stroke and rates of survival. In more rural areas, the ability of hospitals to deliver advanced stroke care is lower and mortality rates substantially higher, the research shows. The analysis, involving […]

The results of this work are presented in the medical journal Blood Advances published by the American Society of Hematology. Routine neonatal screening, although not yet available in Quebec, has led to an increase in the incidence of patients diagnosed with SCID in North America in recent years. This syndrome, a […]

The Recombinant Antibody Network (RAN), a consortium comprising research groups from UC San Francisco, the University of Chicago, and the University of Toronto, has entered into a second research collaboration with Celgene that aims to create and develop high-performance recombinant antibodies against diverse targets in human cells. The first RAN collaboration […]

Yale clinicians report promising results after treating COVID-19 patients at Yale-New Haven Hospital (YNHH) with a drug that reduces hyper inflammation in cancer patients undergoing immunotherapy. The team initially gave the drug, tocilizumab, to the most severely ill COVID-19 patients — specifically, those experiencing a dangerous immune response known as […]

Metastasis accounts for approximately 90 percent of mortality in breast cancer patients. During the last few decades, there has been significant progress in understanding genetic, molecular and signaling mechanisms underpinning cancer cell migration. Biologists from Lawrence Livermore National Laboratory (LLNL) found another mechanism that affects the maintenance and expansion of malignant cells: […]

Having bad teeth hurts your mouth, blood vessels and blood itself, and even your brain. Many people have fear of dentists. But did you know there are dentists for phobic patients too? Visiting an oral health specialist may also have another – often hidden but positive consequence – a potential […]

Professor Vadim Fraifeld, the head of the Laboratory for Biology of Aging, together with his team announced new results from the study in which they have investigated the anti-aging effects of lower body temperature in mice. According to V. Fraifeld, lowering the temperature of biological systems and tissues is currently […]

Each year in Australia, it is estimated 2,400 babies are affected with congenital heart disease. People with complex and severe congenital heart disease require specialist treatment throughout their life. Understanding congenital heart disease and the factors that impact the maternal environment prior to and during pregnancy will be the focus […]

Researchers have created a device that can integrate and interact with neuron-like cells. This could be an early step toward an artificial synapse for use in brain-computer interfaces. In 2017, Stanford University researchers presented a new device that mimics the brain’s efficient and low-energy neural learning process. It was an […]

To defend the body, the immune system makes proteins known as antibodies that latch onto the perceived threat, be it HIV, the new coronavirus or, as is the case in autoimmune disease, part of the body itself. In a new proof-of-concept study in ACS Sensors, researchers describe a new system for […]

The risk of early-onset neonatal bacterial sepsis increases with maternal obesity, according to a new study of the University of Michigan and the Karolinska Institute in Sweden. Lead researcher Eduardo Villamor, a professor of epidemiology at U-M’s School of Public Health, said the study builds on previous research into exposure […]

A new method of screening thousands of drugs in freshly collected human tumor cells could help identify which of the drugs are most likely to be effective against those cancers, report Harvard Medical School researchers based at Dana-Farber Cancer Institute and the Laboratory of Systems Pharmacology at HMS in a study published […]

DNA from uterine cells of women with endometriosis has different chemical modifications, compared to the DNA of women who do not have the condition, according to researchers funded by the National Institutes of Health. The changes involve DNA methylation — the binding of compounds known as methyl groups to DNA […]

Combining more healthy lifestyle behaviors was associated with a substantially lower risk for Alzheimer’s disease in a study that included data from nearly 3,000 research participants. Those who adhered to four or all of the five specified healthy behaviors were found to have a 60% lower risk of Alzheimer’s. The […]

An experimental drug that has been shown to improve the function of diseased and aged mitochondria binds to 12 key proteins involved in energy production, researchers at the University of Washington School of Medicine have found. The drug, elamipretide, also called SS-31, has shown promise for treating rare inherited diseases […]

The benefits of the prostate-specific antigen (PSA) test to screen men for prostate cancer may be greater than the harm, according to a study published in the New England Journal of Medicine. Genitourinary cancer specialists from Seattle Cancer Care Alliance, University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, […]

Vanderbilt University’s Warren Center for Neuroscience Drug Discovery has entered into an exclusive worldwide licensing and collaboration agreement with San Diego-based ACADIA Pharmaceuticals Inc., which will seek to develop and commercialize treatments for central nervous system disorders, such as Alzheimer’s disease and schizophrenia. This collaboration will focus on positive allosteric modulators (PAMs) of […]