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Research produces dramatic results in laboratory studies involving fatal myelin disease that strikes children. A team led by Case Western Reserve University medical researchers has developed a potential treatment method for Pelizaeus-Merzbacher disease (PMD), a fatal neurological disorder that produces severe movement, motor and cognitive dysfunction in children. It results […]

Senolytic drugs that destroy senescent cells, and later on, other senotherapies that either prevent senescence or block the senescence-associated secretory phenotype (SASP), are going to be very important in the treatment of aging. Senescent cells accumulate with age and are highly damaging to tissues. Via the SASP, even comparatively small […]

The age-related decline of the immune system has several causes, but the involution of the thymus is an important one. The thymus is responsible for the production of mature T cells of the adaptive immune system, but the organ atrophies with age. The supply of new T cells falls off […]

There is no situation so terrible that it will not be silently accepted as set in stone, only given that it has lasted for long enough to become routine. So it is with aging, and all of the pain, suffering, and death that accompanies it. The present furor surrounding COVID-19 […]

Increasing abdominal girth and shrinking muscles are two common side effects of aging. Researchers at the University of Bonn have discovered a receptor in mice that regulates both effects. Experiments with human cell cultures suggest that the corresponding signaling pathways might also exist in humans. The study, which also involved […]

Some studies take months to complete, some take years and some can even take decades. When scientists from the University of Birmingham set out to research what kind of effects infant sleep problems have for their adult life, they knew that this study will take a long time. And it […]

Naked mole-rats can live for an incredibly long time and have an exceptional resistance to cancer thanks to unique conditions in their bodies that stop cancer cells multiplying, according to new research. Understanding how these remarkable animals are almost completely immune to cancer could improve our understanding of the early stages […]

By mapping molecular changes in the genome over time, UC San Diego researchers developed a formula to more accurately compare dog age to human age—a tool that could also help them evaluate how well anti-aging products work. If there’s one myth that has persisted through the years without much evidence, […]

Researchers at the University of Alberta have found a way to deliver anti-cancer drugs with more precision, which could increase the effectiveness of many cancer treatments. U of A oncologist Frank Wuest altered the surface of nanoparticles, which are well suited to deliver drugs, with epidermal growth factor (EGF), a peptide that […]

Genomics carries great expectations: the power to help health-care providers assess and assist their patients in managing their individualized risks for common, serious medical conditions, such as cancer and heart disease.  However, how to effectively meld genetic risk assessments into health care is a complex question. Several medical research institutions […]

For hundreds and hundreds of years people have tried to stop the aging process. However, their efforts have never yielded any positive results – there is no youth elixir. Even with the latest scientific advancement we cannot stop the damage that time does on our bodies. But now scientists from […]

Repeated measurements of the biomarker FIB-4 in the blood every few years can predict the risk of developing severe liver disease, according to a new study from Karolinska Institutet published in the Journal of Hepatology. The risk of liver cirrhosis increases if the levels of this biomarker rise between two […]

A new study reveals that the common asthma drug salbutamol may offer potential as a treatment for Alzheimer’s disease. Alzheimer’s disease is the most common form of dementia, affecting 47 million people worldwide and its prevalence is expected to triple to more than 130 million cases by 2050. No effective […]

The article, published in Brain Pathology, describes how SAFB1 expression occurs in both spinocerebellar ataxias and Huntington's disease and may be a common marker of these conditions, which have a similar genetic background. SAFB1 is an important protein controlling gene regulation in the brain and is similar in structure to other […]

USC researchers peering deep inside a living cell have discovered something surprising: Its system for preventing genetic damage linked to diseases can fail so badly that the cell would be better off without it. It’s a paradoxical finding because it challenges the idea that tiny protein guardians of cell division […]

Scientists from the USC Stem Cell laboratories of Neil Segil and Justin Ichida are whispering the secrets of a simpler way to generate the sensory cells of the inner ear. Their approach uses direct reprogramming to produce sensory cells known as “hair cells,” due to their hair-like protrusions that sense sound waves. The study was published […]

Aging sucks. Your entire body starts deteriorating and it’s sad. There is nothing good about aging. But probably the worst part is the decline of cognitive abilities. Losing the sharpness of your mind is truly heartbreaking, but millions and millions of people are facing the inevitability of dementia. However, scientists […]

Companies often outsource some of their activities. It means that some parts of their work are done by other organizations, typically where labour is cheaper or there are other incentives. But humans outsource some of their activities too. Scientists from the University of Queensland found that children begin outsourcing thinking […]

Pretty much half of us is going to get cancer. This is part and parcel of our stressful lifestyle as well as aging. Some substances around us are very efficient in causing cancer. But why is that? Why some chemicals are able to cause cancer, which occurs when errors happen […]

In a series of experiments co-funded by the National Science Foundation, scientists at Johns Hopkins have used light as a trigger to make quick, precise cuts in the genomic material of human cancer cell lines. The researchers cut the DNA within seconds using a molecular scalpel known as CRISPR and were able to […]

Using an enzyme inhibitor in meniscus cells, a Penn team was able to soften their nucleus and promote access to previously impassible areas. By softening a cell’s nucleus so that it can squeeze its way through dense connective tissues, a group of researchers believes they’ve demonstrated a new way to […]

Exercise can slow or prevent the development of macular degeneration and may benefit other common causes of vision loss, such as glaucoma and diabetic retinopathy, new research suggests. A study from the University of Virginia School of Medicine found that exercise reduced the harmful overgrowth of blood vessels in the eyes of […]

A new approach in ophthalmology that offers a revolutionary alternative to corneal transplantation has just been developed by researchers and clinicians in North America, Europe, and Oceania. The team was co-led by May Griffith, a researcher at Maisonneuve-Rosemont Hospital Research Centre, which is affiliated with Université de Montréal and is […]

Powdered sugar is the special ingredient in a Rice University recipe for mimicking the body’s intricate, branching blood vessels in lab-grown tissues. In research published in the journal Nature Biomedical Engineering, Rice bioengineers showed they could keep densely packed cells alive for two weeks in relatively large constructs by creating complex blood vessel […]

A new polymeric heart valve with a life span potentially longer than current artificial valves that would also prevent the need for the millions of patients with diseased heart valves to require life-long blood thinning tablets has been developed by scientists at the universities of Bristol and Cambridge. The team's […]

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide, affecting an estimated one-quarter of the global population. It is a progressive condition that, in worst cases, can lead to cirrhosis, liver cancer, liver failure and death. In a new paper published online in Cell Metabolism, […]

Cambridge-led study discovers new genetic causes of rare diseases, potentially leading to improved diagnosis and better patient care. A research programme pioneering the use of whole genome sequencing in the NHS has diagnosed hundreds of patients and discovered new genetic causes of disease. Whole genome sequencing is the technology used […]

Ribonucleic acid, or RNA, is part of our genetic code and present in every cell of our body. The best known form of RNA is a single linear strand, of which the function is well known and characterized. But there is also another type of RNA, so-called “circular RNA”, or […]

Most traditional cancer therapies target either the tumor cells themselves or indiscriminately kill any rapidly dividing cell. New findings by researchers at University of California San Diego School of Medicine indicate that manipulating macrophages, a type of immune cell found abundantly in the tissues surrounding a tumor, could also be […]

Xiang-Dong Fu, PhD, has never been more excited about something in his entire career. He has long studied the basic biology of RNA, a genetic cousin of DNA, and the proteins that bind it. But a single discovery has launched Fu into a completely new field: neuroscience. For decades, Fu […]