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Led by graduate student Shannon Keenan, the team used light to activate chemical signals in developing fruit flies and traced the effects on a protein called Capicua, or Cic. Located in a cell’s nucleus, Cic binds to DNA and performs the specialized task of silencing genes. The study, published in Developmental Cell […]

New research in mice suggests that certain immune cells may help guide fetal development of the heart and play a role in how the adult heartbeats, according to new research at Washington University School of Medicine in St. Louis. The findings, published in the journal JCI Insight, may help lay […]

Scientists better predict recurrence of prostate cancer for black patients, according to new study; land $3.2 million in federal grants to explore racial bias in cancer diagnosis using Artificial Intelligence, computational imaging. Scientists at Case Western Reserve University are using Artificial Intelligence (AI) to reveal apparent cellular distinctions between black […]

In recognition of this year’s World Cancer Day theme, ‘I Am and I Will’, Professor Pablo Fernandez-Penas talks about how researchers at The Westmead Institute for Medical Research (WIMR) are committed to a world with zero deaths from melanoma. Tell us a bit about your work. I am the co-lead […]

The results of a first-in-human clinical trial of gene therapy to treat a common cause of genetic blindness have shown partial reversal of sight loss in some patients. X-linked retinitis pigmentosa, caused by mutations in RPGR gene, is the most common cause of blindness in young people. The inherited mutations […]

A new study has a group of University of Saskatchewan (USask) researchers taking a look at how high intensity resistance exercises can help adults over the age of 50 who are suffering with bone issues such as osteoporosis. “Ideally, you don’t want someone to be crippled the last 10 or […]

Researchers from Karolinska Institutet along with clinicians from the Karolinska University Hospital have discovered a new molecular mechanism of cell oncogenic signaling switch, which is induced by platinum chemotherapy and contributes to treatment resistance in ovarian cancer. Even with the continuous development of new anti-cancer treatments, chemotherapy is used as […]

But research into the neurological process of learning how to move suggests that it might be more accurate to say “mindful practice makes perfect.” This may not sound revolutionary to anyone who’s ever shot a free throw like LeBron or knocked a golf ball like Nicklaus. Star athletes understand that […]

High blood pressure, or hypertension, affects everything from your arteries to your kidneys, from eyesight to sexual function. Among older adults, high blood pressure is also associated with cognitive decline as a result of interrupted blood flow to the brain, as well as strokes, heart attacks, and impaired mobility. A […]

Neurodegeneration results from a number of neurological conditions affecting older adults, including Alzheimer’s disease and Parkinson’s disease. Treating such diseases is challenging enough, but in recent years, the increased longevity of patients with multiple sclerosis, which also causes neurodegeneration and brain atrophy, has highlighted the need to understand the differences […]

The human immune system can recognize and eliminate not only germs but also cancer cells. This is why treatments with weakened germs can help the immune system in its fight against cancer. Researchers at the Max Planck Institute for Infection Biology in Berlin have genetically modified the tuberculosis vaccine BCG […]

If you want to reduce levels of inflammation throughout your body, delay the onset of age-related diseases and live longer—eat less food. That’s the conclusion of a new study by scientists from the US and China that provides the most detailed report to date of the cellular effects of a […]

NIH-funded project in mice provides insights into why nerves fail to regrow following injury. When the spinal cord is injured, the damaged nerve fibers — called axons — are normally incapable of regrowth, leading to permanent loss of function. Considerable research has been done to find ways to promote the […]

It’s long been known that endurance athletes have larger hearts on average than the rest of the population and that cardiac enlargement is a healthy adaptation to exercise. But what wasn’t known until now was whether the aorta—the main artery leaving the heart and supplying the body with oxygenated blood—followed […]

Scientists from Trinity have identified a rare, new cell in the immune system with “Jekyll and Hyde properties”. These cells play a key protective role in immunity to infection but – if unregulated – also mediate tissue damage in autoimmune disorders. The findings should help us design more effective vaccines […]

Netherton syndrome, a rare skin disease caused by a single genetic mutation, is exacerbated by the presence of two common Staphylococcal bacteria living on human skin, one of which was previously thought to only offer protective properties, report University of California San Diego School of Medicine researchers. “Our study shows how closely […]

Researchers at the University of Southampton have identified how new checkpoint inhibitor treatments for cancer can activate tuberculosis in some patients. Immune therapies for cancer are transforming treatment by activating the body’s immune cells to fight off cancer. Immune checkpoints are part of the human body’s immune system that prevent […]

A study led by the University of Southampton, funded by Cancer Research UK, has shown a new drug – originally developed to tackle the scarring of organ tissue – could help to significantly improve the success rate of cancer immunotherapy treatment. Scientists have shown in mouse cancers, that GKT137831 (Setanaxib) […]

Immune cell activity in the brain differs between males and females in ways that may explain why some neurodegenerative diseases affect the sexes differently, according to a new study from Weill Cornell Medicine scientists. Dr. Li Gan, the Burton P. and Judith B. Resnick Distinguished Professor in Neurodegenerative Diseases in […]

Researchers at Karolinska Institutet in Sweden have analysed all cell types in the human ovary and found that the hotly debated so-called egg stem cells do not exist. The results, published in Nature Communications, open the way for research on improved methods of treating involuntary childlessness. The researchers used single-cell […]

Researchers report an advance in the development of a blood test that could help detect pathological Alzheimer’s disease in people who are showing signs of dementia. This approach could be less invasive and less costly than current brain imaging and spinal fluid tests. The blood test detects the abnormal accumulation […]

Non-small cell lung cancer (NSCLC) patients with higher measures of tumor mutations that show up in a blood test generally have a better clinical response to PD-1-based immunotherapy treatments than patients with a lower measure of mutations. A clinical trial led by researchers from the Perelman School of Medicine at the […]

A simple blood test may soon be able to diagnose patients with two common forms of dementia – Alzheimer’s disease and frontotemporal dementia (FTD) – and tell the two apart. Researchers at UC San Francisco analyzed the blood test in more than 300 patients and say they hope to see […]

Machine-learning algorithms could help improve the accuracy of breast cancer screenings when used in combination with assessments from radiologists, according to a study published in JAMA Network Open. The study was based on results from the Digital Mammography (DM) DREAM Challenge, a crowd-sourced competition to engage an international scientific community to assess whether […]

Turns out, even your cells hate traffic jams. In order for cells to function properly, they need to be able to coordinate traffic within their walls and let information flow in and out. Inside a cell, molecules, organelles and information travel along microtubules, which work like highways or conveyor belts. […]

Researchers from The George Institute for Global Health at the University of Oxford have found that while having high cholesterol levels does not influence your risk of aortic or mitral valve regurgitation, it does increase your risk of developing another major heart valve disease – aortic stenosis. Aortic stenosis is […]

The targeted drug palbociclib may boost the effectiveness of chemotherapy in pancreatic cancer if the two treatments are given in the right sequence, according to new preclinical research by Weill Cornell Medicine and NewYork-Presbyterian investigators. The study, published in Cancer Cell, found that palbociclib may stop pancreatic cancer cells from repairing […]

Errors during cell division can trigger the development of cancer. No wonder that this central process is controlled by multiple regulators and guards. Alex Bird's research group at the Max Planck Institute of Molecular Physiology has discovered a hitherto unknown key player and how it provides the necessary stability to […]

CRISPR-Cas9 has revolutionized the field of genetics by its ability to cut DNA at defined target sites. Researchers are using the Cas9 enzyme to specifically switch off genes, or insert new DNA fragments into the genome. But no matter how specific the Cas9 enzyme is – sometimes it cuts where […]

If the heart pumps too little blood into the body, the brain is usually not adequately supplied with oxygen. Until now, however, it was unclear how this affects brain structure. Researchers at the Max Planck Institute for Human Cognitive and Brain Sciences together with colleagues from the Leipzig Heart Clinic, […]