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The chemical steps in an important cellular modification process that adds a chemical tag to some RNAs have been revealed in a new study. Interfering with this process in humans can lead to neuronal diseases, diabetes, and cancers. A research team, led by chemists at Penn State, has imaged a […]

Using a virus that grows in black-eyed pea plants, nanoengineers at the University of California San Diego developed a new treatment that could keep metastatic cancers at bay from the lungs. The treatment not only slowed tumor growth in the lungs of mice with either metastatic breast cancer or melanoma, […]

In mouse studies, single-cell whole brain imaging found methamphetamines, cocaine and nicotine all changed neural networks — a key to developing addiction treatments Addictive psychostimulants, from nicotine in cigarettes to illicit drugs like methamphetamine and cocaine, affect different regions of the brain. The same is believed true during withdrawal; finding […]

Loss of hair cells in the inner ear is thought to be the primary mechanism behind the progression of age-related hearing loss, though there is some debate over whether it is in fact loss of cells versus loss of the connections that link hair cells to the brain. For some […]

Rejuvenation takes place very early in embryonic development. The germline cells that go into the creation of an embryo are well protected and maintained in comparison to the average somatic cell in the adult body. Nonetheless, there is an accumulation of age-related epigenetic changes and molecular damage. Cells purge themselves […]

Much of the communication between cells is carried in extracellular vesicles, membrane-wrapped packages of signaling molecules. Vesicles are classified by size at present, though the nomenclature is often used confusingly and inconsistently. Exosomes are one class of smaller and frequently studied vesicle. Since it is now comparatively cheap to analyze […]

Some people have a tough character and have trouble establishing close relationships with other people. However, sometimes the inability to relate to the environment and others is linked to managing emotions and making decisions. There may be hallucinations or even a complete lack of emotions. In this case, it may […]

The combination of dasatinib and quercetin was the first practical senolytic therapy explored in mice and human trials. Treatments tended to be one-time (a few doses a few days apart) or weekly over a period of a few months. Here, researchers try a longer term approach, weekly intervals for much […]