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Pre-mRNA splicing in a subset of human short introns is governed by a distinct mechanism involving a new splicing factor. The interrupted non-coding regions in pre-mRNAs, termed “introns,” are excised by “splicing” to generate mature coding mRNAs that are translated into proteins. As human pre-mRNA introns vary in length, the […]

We have only one way to come out of this pandemic – vaccines. And yet many people are hesitant to take them, because of myths, anxiety, distrust of the pharmaceutical industry and actual cases of vaccine-induced immune thrombocytopenia and thrombosis. Now scientists from UCL have a better understanding of the […]

Cells become senescent in response to potentially cancer-inducing stresses and damage, to tissue injury, or when they reach the Hayflick limit on cellular replication. Senescent cells cease to replicate and secrete pro-inflammatory, pro-growth signals. They are cleared by the immune system or via programmed cell death mechanisms. Their presence is […]

This open access paper discusses a secondary issue in the aging of the adaptive immune system. Of primary concern is that the supply of new T cells diminishes over time, due to the atrophy of the thymus where such cells mature, as well as due to issues in the hematopoietic […]

Major depressive disorder, more commonly known as depression, is all too prevalent a part of the human condition. Like many aspects of brain function, a great many layered mechanisms are investigated and debated by the research community, while still being poorly understood as a whole. Pharmaceutical treatments for depression are […]

There are any number of studies to demonstrate that older people are more sedentary than they can be or should be, and that this lack of physical activity has a meaningful negative impact on health and mortality risk. In this example, researchers report on the improved functional status observed in […]

Developed in the University of Arizona Health Sciences Center for Innovation in Brain Science, the therapy has been licensed to startup NeuTherapeutics Inc. University of Arizona researchers have developed a new therapy for Alzheimer's disease designed to restore cognitive function in early-stage patients. The therapy is now proceeding through a […]

Increasing evidence shows that physical activity and exercise training may delay or prevent the onset of Alzheimer’s disease (AD). In aging humans, aerobic exercise training increases gray and white matter volume, enhances blood flow, and improves memory function. The ability to measure the effects of exercise on systemic biomarkers associated […]