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What causes the immune system to err in this way is not clear, but a growing body of research is looking at the trillions of microbes that share our bodies, known collectively as the microbiome, for an answer. Studies of twins indicate that lifestyle, or environmental, factors can play a […]

A urine test based on University of Michigan Rogel Cancer Center research could have avoided one-third of unnecessary prostate cancer biopsies while failing to detect only a small number of cancers, according to a validation study that included more than 1,500 patients. The findings appear in the issue of the Journal of Urology. […]

Scientists in the Perelman School of Medicine at the University of Pennsylvania have uncovered the molecular causes of a congenital form of dilated cardiomyopathy (DCM), an often-fatal heart disorder. This inherited form of DCM — which affects at least several thousand people in the United States at any one time […]

A simple non-invasive test can accurately detect womb cancer according to a proof of concept study by University of Manchester and Manchester University NHS Foundation Trust (MFT) scientists. The non-invasive test, which detects cancer by looking at urine or vaginal sample with a microscope, could have a major benefit for patients if […]

Variants of nine genes increase the risk of developing Addison’s disease, a rare disease in which the immune system attacks the adrenal glands. That is according to the largest genetic study to date on patients with Addison’s disease. The findings help increase knowledge about what causes the disease. The study […]

Neuroblastoma arises within the sympathetic nervous system and is the most frequent extracranial solid childhood cancer, exhibiting a high degree of clinical heterogeneity ranging from spontaneous regression to fatal progression despite intense clinical intervention. Despite extensive sequencing efforts, the number of identified recurrent mutations remain low in pediatric neuroblastoma. Researchers […]

In people with Crohn’s disease, a chronic inflammatory bowel condition, symptoms or how they feel may not line up with actual inflammation in their gut. This mismatch creates challenges for accurately measuring how well a treatment is truly working, especially for children. Currently, many gastroenterologists use symptoms and blood tests […]

A research paper published in the New England Journal of Medicine has revealed that a new anti-obesity medication is almost twice as effective in helping people lose weight than other current weight loss drugs. Professor John Wilding, who leads clinical research into obesity, diabetes and endocrinology at the University of […]

Glycomics researchers at the University of Alberta and CHU Sainte-Justine have reported a discovery that could lead to new treatments for cardiovascular disease. The researchers identified a new mechanism responsible for the buildup of plaque on artery walls, a process known as atherosclerosis. This plaque, made up of fats, cholesterol […]

Genetics and multi-omic information could one day inform treatments for glioblastoma. The largest and most detailed molecular analysis yet of an aggressive brain cancer, called glioblastoma, reveals fundamental details that drive its growth. The work, led by a team of scientists from the U.S. Department of Energy’s (DOE) Pacific Northwest […]

Dance is considered as one of the art forms. Regardless of whether we do it professionally or as a hobby, it gives us great pleasure, relaxes, and allows us to break away from the prose of life. Thus, dance can be beneficial for our mind, memory, stimulation of the nerve […]

IMDEA Nanociencia researchers measure the nanoscale heating of gold-based nanoparticles and find high temperature variations within a nanoscopic volume. In hyperthermia treatments, the temperature is raised above physiological levels to induce the death of cancerous cells. The local application of hyperthermia is key for a successful treatment and to reduce […]

Researchers at the Garvan Institute of Medical Research have developed a computational model to calculate ‘skeletal age’, a personalised estimate of an individual’s risk of bone fracture and premature death. The skeletal age calculator, which will be accessible to doctors and health professionals, aims to better identify those at risk […]

Exposure to radiation can wreak indiscriminate havoc on cells, tissues, and organs. Curiously, however, some tissues are more vulnerable to radiation damage than others. Scientists have known these differences involve the protein p53, a well-studied tumour-suppressor protein that initiates a cell’s auto-destruct programs. Yet, levels of this sentinel protein are […]

NIH researchers take “deep dive” into brain’s transcriptome. A new study suggests that differences in the expression of gene transcripts – readouts copied from DNA that help maintain and build our cells – may hold the key to understanding how mental disorders with shared genetic risk factors result in different patterns […]

Did you know that heart attack and stroke are the number one cause of premature death for women in Canada? Or that Canadian women are five times more likely to die of heart disease than breast cancer? Or that 53 per cent of women who have heart attack symptoms go […]

New research at the University of Alberta has revealed a way to increase the sensitivity to immunotherapy of a rare type of cells within a tumour that are responsible for treatment resistance and breast cancer progression. The study, recently published in the journal Cancer Letters, could pave the way to better treatment […]

Professor Kimitaka Nakazawa, a specialist in neurorehabilitation, first had the opportunity to study the brain activity of a Paralympic gold medalist in January 2016, when he visited a university pool in the United States as part of an NHK television program called “Chojin-tachi no Paralympic” [The superhuman Paralympians]. He was […]

Rice University’s programmable CRISPR/Cas9-based kinase offers insights into, control over regulatory histone proteins. Finding a needle in a haystack is hard enough. But try finding a specific molecule on the needle. Rice University researchers have achieved something of the sort with a new genome-editing tool that targets the supporting players […]

COVID-19 is a very dangerous disease, but risks are not equal to everyone. Older people are facing higher risks of complications from COVID-19 and should be protected more. Now scientists at the University of Birmingham have shown that frail individuals are much more likely to die from COVID-19. Frailty is […]

Scientists from Skoltech and A.I. Burnazyan Federal Medical and Biophysical Center have designed and developed a second opinion system, based on AI-assisted video analysis, which can help medical professionals to objectively assess patients with Parkinson’s disease (PD) even at an early stage. This approach can help avoid misdiagnosing this disease, […]

We know that what happens in the mouth doesn’t stay in the mouth – but the oral cavity’s connection to the rest of the body goes way beyond chewing, swallowing and digestion. The healthy human oral microbiome consists of not just clean teeth and firm gums, but also energy-efficient bacteria […]

A new approach to treating one of the leading causes of blindness among patients with diabetes is being tested in clinical trials which begin this month. The trial involves 48 patient volunteers with diabetic macular oedema (DMO), a disease where blood vessels leak fluid into the retina. It is the […]

At any moment in the human body, in about 30 trillion cells, DNA is being “read” into molecules of messenger RNA, or mRNA, the intermediary step between DNA and proteins, in a process called transcription. Scientists have a good idea of how transcription gets started. Proteins called RNA polymerases are […]

Dynamic, delicate connection between protein filaments enables hearing. The sense of hearing is, quite literally, a molecular tightrope act. Turns out, it involves acrobatics as well. In a paper published in Nature Communications, researchers at Harvard Medical School and Boston Children’s Hospital show that a dynamic and delicate connection between two […]

In cells, numerous important biochemical functions take place within spherical chambers made from proteins and RNA. These compartments are akin to specialized rooms inside a house, but their architecture is radically different: They don’t have walls. Instead, they take the form of liquid droplets that don’t have a membrane, forming […]

While eating less and moving more are the basics of weight control and obesity treatment, finding ways to help people adhere to a weight-loss regimen is more complicated. Understanding what features make a diet easier or more challenging to follow can help optimize and tailor dietary approaches for obesity treatment. […]

A University of Iowa study finds people who work long-term in the agricultural industry have 46% greater odds of developing dementia than those in other fields. Professor Kanika Arora in the U-I College of Public Health, says hearing impairment, depression and isolation can all be linked to dementia and to […]

Findings from a new study on Alzheimer’s disease (AD), led by researchers at the University of Saskatchewan (USask), could eventually help clinicians identify people at highest risk for developing the irreversible, progressive brain disorder and pave the way for treatments that slow or prevent its onset. The research, published in […]

Neuroscientists at McMaster University have found a link between children who are at risk for developmental coordination disorder (DCD), a common condition that can cause clumsiness, and difficulties with time perception such as interpreting changes in rhythmic beats. Accurate time perception is crucial for basic skills such as walking and […]