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Senescent cell accumulation is a feature of aging, a growing imbalance between the rate of creation and rate of destruction. Senescent cells perform a number of useful tasks in the short-term, but when present for the long-term, their inflammatory secretions disrupt tissue function and contribute meaningfully to the onset and […]

Senolytic treatments are those that selectively destroy senescent cells, a form of intervention that has produced rejuvenation in older animals. A high dose of the flavonol fisetin is not yet proven to be usefully senolytic in humans, but has shown a surprising degree of efficacy in mice. The only senolytic […]

New study identifies molecular players in ‘dead man’s switch’ that triggers key immune organ’s regeneration after damage. The pandemic has put immune function — and how to boost it — at top of mind. Most recommendations for boosting immune responses focus on lifestyle choices, including adequate sleep, a solid exercise […]