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Tooth loss is often accepted as a natural part of ageing, but what if there was a way to better identify those most susceptible without the need for a dental exam? New research led by investigators at Harvard School of Dental Medicine suggests that machine learning tools can help identify […]

Children with obstructive sleep apnea are nearly three times more likely to develop high blood pressure when they become teenagers than children who never experience sleep apnea, according to a new study funded by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health. However, […]

National Institutes of Health scientists and their collaborators have identified an internal communication network in mammals that may regulate tissue repair and inflammation, providing new insights on how diseases such as obesity and inflammatory skin disorders develop. The new research is published in Cell. The billions of organisms living on body […]

To better understand the role of bacteria in health and disease, National Institutes of Health researchers fed fruit flies antibiotics and monitored the lifetime activity of hundreds of genes that scientists have traditionally thought control aging. To their surprise, the antibiotics not only extended the lives of the flies but […]

In children with rhabdomyosarcoma or RMS, rare cancer that affects the muscles and other soft tissues, the presence of mutations in several genes, including TP53, MYOD1, and CDKN2A, appears to be associated with a more aggressive form of the disease and a poorer chance of survival. This finding is from the largest-ever […]

Researchers at Washington University School of Medicine in St. Louis have identified ingredients for snack food prototypes that have been formulated to deliberately change the gut microbiome in ways that can be linked to health. Translating results from animal models, the scientists have shown in two pilot human studies of […]

Early in the COVID-19 pandemic, scientists identified how SARS-CoV-2, the virus that causes COVID-19, gets inside cells to cause infection. All current COVID-19 vaccines and antibody-based therapeutics were designed to disrupt this route into cells, which requires a receptor called ACE2. Now, researchers at Washington University School of Medicine in […]

The canine disease granulomatous meningoencephalomyelitis (GME), the most common neuroinflammatory disease that affects dogs, shares key features of its pathology and immunology with multiple sclerosis (MS), according to a new study. A detailed investigation of GME by a team led by Molly Church and Jorge Iván Alvarez of Penn’s School of Veterinary Medicine, incorporating MRI […]

Thanks to researchers in different fields who put in nearly two decades of past work on mRNA vaccine technology, people around the world are being immunized today from COVID-19 — and hopefully leading us out of this pandemic. Now, because of the increased focus on this versatile technology and that foundation […]

A Canadian research team has uncovered a new mechanism involved in Bourneville tuberous sclerosis (BTS), a genetic disease of childhood. The team hypothesizes that a mutation in the TSC1 gene causes neurodevelopmental disorders that develop in conjunction with the disease. Seen in one in 6,000 children, tuberous sclerosis causes benign […]

Researchers at UC San Francisco have found that extreme caloric restriction diets alter the microbiome in ways that could help with weight loss but might also result in an increased population of Clostridioides difficile, a pathogenic bacterium that can lead to severe diarrhoea and colitis. Such diets, which allow people only […]

Bone cancer is hard to treat and prone to metastasis. Research teams at Rice University and Baylor College of Medicine have a new strategy to attack it. Chemist Han Xiao at Rice and biologist Xiang Zhang at Baylor and their labs have developed an antibody conjugate called BonTarg that delivers drugs to bone tumors and inhibits […]