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Glutathione is a mitochondrial antioxidant, and additional antioxidant capacity in mitochondria appears to be beneficial to long-term health, improving mitochondrial function and overall health. Mitochondria conduct the energetic process of producing ATP, used to power the cell, with a flux of oxidative molecules as a side-effect. With age, mitochondria tend […]

Research from a University of Saskatchewan (USask) College of Medicine team will help develop medications that can inhibit the nerve cell damage that occurs due to diseases such as multiple sclerosis (MS). The research team has modelled the mechanisms by which a specific cell protein, A1, causes damage to nerve […]

In recent years, researchers have established that machine learning approaches can be used to produce any number of clocks from biological data that shifts with age, finding patterns that match chronological or biological age to a great enough accuracy to suggest that they can be useful assays for the assessment […]

While they cannot explain aging as a whole, single cause theories of aging can be useful tools to frame discussion and investigation aimed at better understanding aging and its evolution. The theory presented here is aging viewed through the lens of cancer, two entwined processes. Aging is viewed as largely […]

There is, in general, a growing appreciation of the relevance of previously dismissed mechanisms of damage in the pathology of common age-related disease, such as cardiovascular conditions. The biggest challenge in aging and age-related disease is perhaps less the identification of relevant mechanisms, but rather understanding the relative importance of […]

A new treatment may be on the horizon for people suffering from Crohn’s disease after a McMaster University-led study identified serotonin as a possible trigger of flare-ups. Scientists discovered that increased levels of serotonin hormones prevent gut cells from carrying out autophagy, the routine ‘housework’ of the gut cleaning out […]