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Patients with Alzheimer’s disease and other forms of dementia commonly experience sundown syndrome: a sudden worsening of confusion, agitation and aggression at the end of the day. This daily pattern suggested that sundowning, as the phenomenon is also known, may be governed by the body’s internal biological clock. Synchronized by […]

You’ve heard of the face that launched a thousand ships? Margaret “Peg” Geisler, 82, is the case that launched an international search for “extreme survivors” of metastatic breast cancer. Geisler, a retired UW–Madison director of outreach development, has lived with breast cancer for 40 years and with metastatic cancer (meaning it spread […]

Researchers at the National Institutes of Health worked with 15 patients from around the world to uncover a genetic basis of “dripping candle wax” bone disease. The rare disorder, known as melorheostosis, causes excess bone formation that resembles dripping candle wax on x-rays. The results, appearing in Nature Communications, offer […]

A new Tel Aviv University study addresses the challenges of nanoparticle-based cancer-targeting strategies. It also suggests ways of refocusing the collaborative work of cancer researchers and clinicians to move the field forward from “the bench” to the patients. The study follows landmark research published 10 years ago in Nature Nanotechnology that reviewed the full […]

Many cancers start with the flip of a switch. For example, the most common mutation in human cancers affects a small signaling protein called K-Ras, which helps tell our cells when to grow and divide; when K-Ras is mutated, its normal on-off mechanism gets stuck in the “on” position, leading […]

Mothers aged 30 to 34 years have more full-term pregnancies and healthier babies than those in the 20-to-24 age group. These are the findings of a new  epidemiological study led by an Université de Montréal researcher which looked at over 165,000 births in 32 Quebec hospitals from 2008 to 2011. “We’ve always […]

Regularly drinking more than the recommended UK guidelines for alcohol could take years off your life, according to new research from the University of Cambridge. Part-funded by the British Heart Foundation, the study shows that drinking more alcohol is associated with a higher risk of stroke, fatal aneurysm, heart failure […]

Age-related macular degeneration (AMD) affects more than 1.75 million individuals in the United States. Because the population is aging, that number will increase to almost 3 million by 2020. Between 80 and 90 percent of cases in this country are the dry version of the condition, for which no effective treatment exists. Now, a team […]

University of Queensland researchers have highlighted a link between fetal brain development and the origins of developmental diseases such as schizophrenia. UQ Faculty of Medicine’s Dr Liam Coulthard said many adult diseases originated during fetal development. “Complement factors – part of the immune system that kills bacteria and helps white […]

Researchers at the University of Washington have designed a convenient and natural product that uses proteins to rebuild tooth enamel and treat dental cavities. The research finding was first published in ACS Biomaterials Science and Engineering. “Remineralization guided by peptides is a healthy alternative to current dental health care,” said lead […]

Cancer is a horrible disease and one of the major causes of death. Humanity is getting closer to curing cancer. In fact, most cancer patients survive for a pretty long time these days. However, wouldn‘t it be great if we could simply vaccinate against cancer? Scientists from the University of […]

In humans and other mammals, the female reproductive cells – the eggs or oocytes – need nourishment in order to grow and remain fertile. It is known that the egg gets its food from little arm-like feeding tubes (called filopodia) that jut out from tiny cells surrounding the egg and […]

Glaucoma is one of the leading causes of blindness around the world. It is hard to treat and even approved methods are not very effective. For example, drops can deliver some medication to the eye, but they have one significant drawback – only around 5 % of the liquid stays […]

Researchers at the University of Liverpool have developed a mathematical model that has the potential to improve the performance of endovascular aneurysm sealing (EVAS), which is an innovative procedure to treat abdominal aortic aneurysms (AAA). AAA is a swelling of part of the aorta inside the abdomen caused by a […]

  Harvard Medical School researchers at Massachusetts Eye and Ear have shown that mifepristone, a drug currently FDA-approved for chemical abortion, prevents the growth of vestibular schwannoma (also known as acoustic neuroma) cells. This sometimes-lethal intracranial tumor typically causes hearing loss and tinnitus. The findings, published online in Scientific Reports, suggest that […]

People with the rare disease called primary progressive aphasia may recruit intact brain areas for help with language, according to a new UA-led study. People with a rare dementia that initially attacks the language center of the brain recruit other areas of the brain to decipher sentences, according to new […]

Researchers are now able to use induced pluripotent stem cells (iPSC) to form a model of human adult-like cardiac muscle by introducing electric and mechanical stimulation at an early stage. Since this muscle is similar to the adult heart, it could serve as a better model for testing the effects […]

Researchers supported by the National Institutes of Health have uncovered molecular characteristics that link the genomic profiles of squamous cell carcinomas (SCCs) from five areas of the body and that set these SCCs apart from other cancers. Using a robust dataset of SCCs from the head and neck, lung, esophagus, […]

Researchers funded by the National Institutes of Health have completed a detailed genomic analysis, known as the PanCancer Atlas, on a data set of molecular and clinical information from over 10,000 tumors representing 33 types of cancer. “This project is the culmination of more than a decade of groundbreaking work,” […]

Transmissible cancers are incredibly rare in nature, yet have arisen in Tasmanian devils on at least two separate occasions. New research from the University of Cambridge identifies key anti-cancer drugs which could be trialled as a treatment for these diseases, which are threatening Tasmanian devils with extinction. The research also […]

Cancer lurking in tissue could be more easily found when looking through a butterfly’s eye. Researchers at the University of Illinois at Urbana-Champaign and Washington University in St. Louis have developed a surgical camera inspired by the eye of the morpho butterfly. The camera, connected to the goggles a surgeon […]

Conflict, a death in the family, financial hardship and serious medical crises are all associated with accelerated physical aging. In a new study, researchers at the University of California San Diego School of Medicine found that such negative fateful life events — or FLEs — appear to also specifically accelerate […]

Currently, the main treatments for Alzheimer’s disease are drugs that increase levels of acetylcholine in the brain. The University of Bristol paper, published in Cell Reports, describes the role two main types of nicotinic receptor (α7 and α4β2 receptors) play in long-term memory retrieval and encoding – and the impact of […]

University of Queensland researchers have developed a vaccine delivery technology that enables treatment to be tailored precisely for different cancers. UQ’s Professor Ranjeny Thomas said the technology had the potential to improve the precision of cancer immunotherapy, leading to better cancer outcomes and reduce harmful side-effects. “Flexible cancer vaccines are […]

From the Universities of Oxford, Bristol and Johannesburg, the researchers argue that for some people a reduced level of kidney function is not necessarily a disease, but a normal and asymptomatic sign of ageing, given the clear link between decreasing kidney health and increasing age. Since 2002, the different stages of CKD […]

Case Western Reserve University’s Center for Computational Imaging and Personalized Diagnostics (CCIPD) is leading a partnership working toward the first clinical trials to determine the aggressiveness of—and appropriate treatment for—certain head and neck cancers. Head and neck cancers (squamous cell carcinomas or HNSCC) represent more than a half-million cases and 300,000 deaths […]

People are born with some conditions even though diagnosis doesn‘t come immediately. Scientists from the University of Queensland have developed a method to identify infants who will grow to develop type 1 diabetes. This will lead to better ways to conduct screenings in order to identify children at the highest […]

Scientists have designed a new drug compound that dials down inflammation, suggesting possible future uses against autoimmune disorders such as rheumatoid arthritis. The new inhibitor is more selective than other compounds designed to target the same inflammatory pathway, according to new research from Washington University School of Medicine in St. […]

Years before people start showing characteristic symptoms of Alzheimer’s disease, sticky plaques begin forming in their brains, damaging nearby cells. For decades, doctors have sought ways to clear out these plaques as a way to prevent or treat the disease. The sticky clumps, known as amyloid plaques, are composed primarily […]

For a stem cell, the future is wide open. It can divide infinitely to create more stem cells, or it can grow up into other kinds of cells, taking its place in the heart, brain, or other organs. But the stem cell loses something during that maturation: its remarkable ability […]