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Using routinely acquired pathology slides, the model accurately predicts the origin of cancers with unknown primary tumors. In 1 to 2 percent of cancer cases, the primary site of tumor origin cannot be determined. Because many modern cancer therapeutics target primary tumors, the prognosis for a cancer of unknown primary […]

It turns out the 'bad guys' of the brain aren't so bad after all. When there’s damage in the body, our cells call for help. UConn brain researchers just found a new way cells do this—like in the old AT&T ad campaign, they reach out and touch someone. Or some […]

A revolution is coming to Mizzou. Instead of a rabble, it’s genteel scientists inciting this upheaval, which comes in the form of large, shiny instruments that can peer deep inside bodies, individual cells and even molecules — all in remarkable detail. One machine so huge that a crane must lift […]

When you’re solving a challenging math problem, you know your brain is working hard. But what, exactly, is going on in there? Despite decades of research into math teaching and learning, there is still much to learn about how specific brain functions are tied to math skills. A new University […]

New research from the University of Virginia School of Medicine reveals why sleep can put people with epilepsy at increased risk of sudden death. Both sleep and seizures work together to slow the heart rate, the researchers found. Seizures also disrupt the body’s natural regulation of sleep-related changes. Together, in […]

Hyaluronic acid (HA) is more than a buzzword ingredient touted by skincare brands. The “workhorse” capabilities of this biopolymer, which is present in most mammalian tissues, have fascinated scientists for decades. A new cover story in Chemical & Engineering News, the weekly newsmagazine of the American Chemical Society, details HA’s complex […]

A study involving researchers at Karolinska Institutet and Gothenburg University has found that low levels of a protein called PDGFRb are associated with particularly good results of radiotherapy in women with early-stage breast cancer. The study, which is published in the journal Clinical Cancer Research, also suggests that the efficacy […]

Older people with kidney disease have a higher risk of dementia, and the risk increases with the rate and stage of kidney function decline. That is according to a large observational study by researchers at Karolinska Institutet in Sweden, published in the journal Neurology. The findings stress the significance of […]

Researchers have mapped the gene activity of osteocytes to improve their understanding of skeletal disease. Research led by the Garvan Institute of Medical Research has for the first time mapped the unique genetic profile of the skeleton’s ‘master regulator’ cells, known as osteocytes. The study published in Nature Communications outlines the […]

Determining safe yet effective drug dosages for children is an ongoing challenge for pharmaceutical companies and medical doctors alike. A new drug is usually first tested on adults, and results from these trials are used to select doses for pediatric trials. The underlying assumption is typical that children are like […]

For all animals, eliminating some cells is a necessary part of embryonic development. Living cells are also naturally sloughed off in mature tissues; for example, the lining of the intestine turns over every few days. One way that organisms get rid of unneeded cells is through a process called extrusion, […]

A new study from scientists at The Irish Longitudinal Study on Ageing (TILDA) at Trinity College Dublin reveals important findings, indicating that being overweight or obese significantly reduces blood flow in the brain. The study also shows that increased physical activity can positively modify, or even negate, this reduction in […]