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As cancer patients become increasingly ill toward the end of their lives, their pain often intensifies and increases in frequency. This is distressing not only to the patient, but also to the patient’s caregivers, often a spouse or partner. Effectively managing that pain with medications and other therapies is of […]

Researchers at the University of Tokyo revealed that a phosphorous-containting lipid in the membrane plays a critical role in activating a protein involved in the transcription of genes regulating cell proliferation. This research outcome points to new drug targets for malignant cancer cells where this signaling pathway is involved. The […]

Three years ago, on one cold March afternoon, James Costello slipped on black ice. He hit his head hard enough that he expected the worst: a concussion. Although he was feeling a bit off, he continued his usual duties—trekking eight miles a day as a mail carrier in South Jersey. […]

The concept of survival of the fittest most often applies to the competition that occurs within and between animal species, but evolutionary pressures can be found elsewhere—even in a cancerous tumor. Cancer researchers have come to understand tumors not as lumps of identical cells, but rather as diverse, dynamic populations […]

UA research has resulted in a melanin-producing compound for a systemic approach to preventing skin damage. The University of Arizona has licensed two inventions developed in the Department of Chemistry and Biochemistry to startup MCR Therapeutics. The inventors, Minying Cai and Victor J. Hruby, developed targeted peptides through their research […]

People with a gene variant called APOE4 have a higher risk of developing late-onset Alzheimer’s disease: APOE4 is three times more common among Alzheimer’s patients than it is among the general population. However, little is known about why this version of the APOE gene, which is normally involved in metabolism […]

Memory, learning and cognitive flexibility depend on a protein 'off-switch' in the brain, according to a breakthrough discovery made by an international research collaboration co-led by the University of Warwick. This new knowledge could enable us to better understand and combat neurological diseases which inhibit memory, such as Alzheimer's. Dr […]

In your body, blood stem cells produce approximately 10 billion new white blood cells, which are also known as immune cells, each day. Even more remarkably, if some of these blood stem cells fail to do their part, other blood stem cells pick up the slack and overproduce whichever specific […]

The research, published in the journal Nature Genetics, in the future aims to enable the prediction of the trajectory of tumour growth in patients, allowing clinicians to pre-empt disease course and tailor treatment regimens accordingly. The model was developed in collaboration with researchers from Barts Cancer Institute’s Centre for Tumour Biology, led by Professor […]

A new discovery about the effects of aging in our cells could allow doctors to cure or prevent diabetes, fatty liver disease and other metabolic diseases – and possibly even turn back the clock on aging itself. The new finding from the University of Virginia School of Medicine suggests that […]

After a decade of work, a team led by Hôpital Maisonneuve-Rosemont researcher and Université de Montréal associate professor Dr. Gilbert Bernier has shed promising light on the origin of the most common and prevalent form of Alzheimer’s disease, hoping to someday help mitigate or even reverse the progress of the […]

An in utero stem cell transplant for a critically ill second-trimester fetus has led to the birth of an apparently healthy infant. The newborn is the first patient enrolled in the world’s first clinical trial using stem cells transplanted prior to birth. The infant was born at UCSF Benioff Children’s […]