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New findings suggest that late-onset Alzheimer’s Disease is driven by epigenetic changes—how and when certain genes are turned on and off—in the brain. Results were published in Nature Genetics. Research led by Raffaella Nativio, a former research associate of epigenetics, Shelley Berger, a professor of genetics, biology and cell and developmental diology and director […]

Women receiving fertility-sparing surgery for treatment of borderline ovarian tumours were able to have children, a study from Karolinska Institutet in Sweden published in Fertility & Sterility shows. Natural fertility was preserved in most of them and only a small proportion required assisted reproductive treatment such as in vitro fertilization. […]

One of the biggest challenges to the development of medical treatments for cancer is the fact that there is no single kind of cancer. Cancers derive from many kinds of cells and tissues, and each has their own characteristics, behaviours, and susceptibilities to anti-cancer drugs. A treatment that works on […]

Middle-aged adults who report symptoms of insomnia and are sleeping less than six hours a night may be at increased risk of cognitive impairment, according to a study by Penn State College of Medicine researchers. The results may help health care professionals understand which patients who report insomnia are at […]

High-grade serious ovarian carcinoma (HGSOC) is the fifth-leading cause of cancer-related deaths in women in the United States, yet little is known about the origins of this disease. Now, scientists at the College of Veterinary Medicine have collaborated on a study that pinpoints which specific genes drive – or delay […]

A new study in mice helps explain why gut microbiomes of breastfed infants can differ greatly from those of formula-fed infants. The study, “Dietary Sphinganine Is Selectively Assimilated by Members of the Mammalian Gut Microbiome,” was published in the Journal of Lipid Research. The paper describes an innovative technique developed […]

A study of almost 400,000 British participants has identified a new link between raised levels of the growth factor IGF-1 and increased thyroid cancer risk and has confirmed associations with breast, prostate and colorectal cancer. This could lead to new preventative strategies, including diet and lifestyle interventions. IGF-1 (insulin-like growth […]

Differences in the shape and texture of men and women's hearts could potentially explain why their risk of heart disease differs, according to research funded by the British Heart Foundation (BHF). The findings were presented at the European Society of Cardiology (ESC) Congress. Researchers at Queen Mary University of London, […]

A team of scientists, led by King’s College London, have discovered an unexpected tissue reparative role for a rare immune cell type in the gut that could tip toward fibrosis or cancer if abnormal or impaired. The breakthrough, revealed in a paper published in Nature Materials, will have important implications for […]

About 1 in 5 new breast cancers are caught at their earliest stages, before they’ve spread from milk ducts into the surrounding breast tissue. But what doctors can’t currently predict with high confidence is which of these cancers — known as ductal carcinoma in situ (DCIS) or stage 0 breast cancer — […]

Heart failure with preserved ejection fraction, or HFpEF, occurs when the contraction of the heart muscle is able to pump blood normally and subsequently has a preserved ejection fraction, but the heart chambers are too stiff to relax and fill properly. In the United States, HFpEF numbers are on the […]

As a high school student, junior Darcey Hookway spent time volunteering on a dementia ward at a local hospital. “The social aspect of their condition really struck me,” says Hookway, who is from London. “They struggled immensely with social isolation. And now with COVID exacerbating that more than ever, I […]