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Telomeres are the protective caps of our chromosomes and play a central role in the ageing process. Shorter telomeres are associated with chronic diseases and high stress levels can contribute to their shortening. A new study now shows that if telomeres change in their length, that change is also reflected […]

A completely new, comprehensive human genome reference will be created in a National Institutes of Health-funded, multi-institutional initiative. The Human Pangenome Project will be based on the complete genome sequences of 350 individuals from a variety of the world’s populations. The international Human Genome Project in 2000 produced the first working draft […]

The Yale laboratory of Sidi Chen, assistant professor of genetics in the Systems Biology Institute and Yale Cancer Center, has developed advanced gene-editing and screening technology to find new targets for cancer immunotherapy. In a new study published in Nature Biotechnology, Chen and colleagues report that using T cells containing […]

New grants totaling approximately $29.5 million will enable scientists to generate and maintain the most comprehensive reference sequence of the human genome. The awards, made over five years pending the availability of funds, are managed by the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health. […]

According to a recent study published in Proceedings of the National Academy of Sciences of the United States of America, the biological clock influences immune response efficacy. Indeed, CD8 T cells, which are essential to fight infections and cancers, function very differently according to the time of day. The study was […]

Many neurodegenerative diseases have a common feature that may make them amenable to the same treatment, investigators at the Stanford University School of Medicine have found. “We’ve identified a potential new way to reduce nerve-cell death in a number of diseases characterized by such losses,” said Daria Mochly-Rosen, PhD, professor of chemical and […]

Over the past three years, in hopes of accelerating research on the genetic causes and treatments for autism, University of Miami psychology faculty have recruited nearly 700 children affected by the neurodevelopmental disorder, and both of their parents, to join the world’s largest autism research project. This month they began […]

A treatment for psoriasis could be repurposed to treat a rare but aggressive form of youth cancer, new findings from the Garvan Institute of Medical Research suggest. In an animal model, researchers demonstrated that the immune molecule IL23 is central to the development of osteosarcoma, a cancer of the bone. […]

Which treatment will benefit this patient best? Which substances are most promising for pharmaceuticals companies to develop? These are questions that scientists at Linköping University are seeking to answer with the aid of the tiny zebrafish embryo. Zebrafish embryos are colourless transparent balls. We see some only a few days […]

Restricting sleep for just several days alters how we metabolize fats and changes how satisfied we are by a meal, according to new research conducted at Penn State and published in the Journal of Lipid Research. According to Orfeu Buxton, researcher on the project and professor of biobehavioral health at Penn […]

For patients diagnosed with a certain type of brain cancer called glioblastoma, long-term survival is rare. Surgery can remove tumors visible to the surgeon’s eye. It cannot, however, take out the diseased tendrils of tumor cells that extend beyond what the doctor sees. While current immunotherapy drugs are effective for […]

A drug used to treat chronic myeloid leukemia appears to be more effective at stopping a type of medulloblastoma in mouse models than existing treatments for the deadly pediatric brain tumor, reports a multi-institutional team led by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California […]