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To catch cancer earlier, we need to predict who is going to get it in the future. The complex nature of forecasting risk has been bolstered by artificial intelligence (AI) tools, but the adoption of AI in medicine has been limited by poor performance on new patient populations and neglect to racial minorities. […]

Building on the promise of emerging therapies to deploy the body’s “natural killer” immune cells to fight cancer, researchers at the University of Michigan Rogel Cancer Center and U-M College of Engineering have gone one step further. They’ve developed what is believed to be the first systematic way to catch natural killer cells and get […]

The ability to understand others’ hidden thoughts and beliefs is an essential component of human social behaviour. Now, neuroscientists have for the first time identified specific neurons critical for social reasoning, a cognitive process that requires individuals to acknowledge and predict others’ hidden beliefs and thoughts. The findings, published in Nature, […]

The answer to the age-old mystery of the evolutionary origins of vertebrate eyes may lie in hagfish, according to a new study by biologists at the University of Alberta. “Hagfish eyes can help us understand the origins of human vision by expanding our understanding of the early steps in vertebrate […]

In many ways, our brain and our digestive tract are deeply connected. Feeling nervous may lead to physical pain in the stomach, while hunger signals from the gut make us feel irritable. Recent studies have even suggested that the bacteria living in our gut can influence some neurological diseases. Modelling […]

Using a novel technique for expanding tissue, MIT and Harvard Medical School researchers have devised a way to label individual molecules of messenger RNA within a tissue sample and then sequence the RNA. This approach offers a unique snapshot of which genes are being expressed in different parts of a […]

Porphyrins are interesting drug delivery vehicles that can specifically accumulate in cancer cells. However, how the structure of the drug-conjugated porphyrin affects its ability to penetrate and accumulate within cancer cells is not well understood. Researchers from Tokyo University of Science now investigate the correlation between the structure and tumor […]

Advanced glycation endproducts (AGEs) are a form of metabolic waste, sugary compounds that can interact harmfully with structures and cells in the body. A few forms of persistent AGE can form lasting cross-links in the extracellular matrix that change the structural properties of tissues, contributing to the loss of elasticity […]

It was an unexpected discovery that started with an analysis of more than 1,000 genes. The question: why game-changing cancer immunotherapy treatments work for only a fraction of patients. The analysis shone a light on one that popped up repeatedly in patients and mouse models that did not respond to […]

Working to develop new treatments for osteoarthritis, researchers at Washington University School of Medicine in St. Louis have genetically engineered cartilage to deliver an anti-inflammatory drug in response to activity similar to the bending of a knee or other motions that put stress on joints. Among the early symptoms of […]

What makes one person drive above the speed limit while another navigates steadily in the right lane? What motivates someone to leave a job with a steady paycheck to launch their own business while the other sticks to one employer for an entire career? “People have different tendencies to engage […]

A new University of Alberta study shows that losing weight before knee replacement surgery doesn’t lead to better outcomes for patients. In a systematic review published in Joint Bone Spine, researchers in the Faculty of Rehabilitation Medicine found that weight loss before surgery may not be beneficial for people with advanced knee osteoarthritis. Medical practitioners have long advised […]