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Sports concussions, Parkinson’s disease and hormone therapy for cancer all can have memory loss as symptoms. But can the biochemical processes of each reveal anything about the memory loss associated with Alzheimer’s disease? Rong Xu recently received a total of $5 million from the National Institute of Health’s (NIH) National […]

There is a large, untapped potential for developing drugs against cancer, fibrosis and cardiovascular diseases by targeting a family of receptors known as Frizzleds, researchers at Karolinska Institutet in Sweden believe. In a new study published in Science Signaling, they identify how these receptors are activated in the cell membrane and […]

Purdue University research shows the antidote can effectively remove acrolein, a neurotoxin produced in the body that is directly correlated with Parkinson’s disease. A World War II chemical weapon antidote is shown to be effective combating a new enemy: Parkinson’s disease. Parkinson’s is characterized by the steady and progressive loss […]

Epigenetics is the expression and control of genes. The epigenetics involved in the inner ear is a critical part of the mystery of hearing. A team led by Prof. Karen B. Avraham, Vice Dean of the Sackler Faculty of Medicine at Tel Aviv University, has now created the first map of “methylation” — one […]

The National Institutes of Health announced that enrollment for the Adolescent Brain Cognitive Development (ABCD) Study is now complete and, in early 2019, scientists will have access to baseline data from all ABCD Study participants. There are 11,874 youth, ages 9-10, participating in the study, including 2,100 young people who […]

For the first time, bioengineered spinal discs were successfully implanted and provided long-term function in the largest animal model ever evaluated for tissue-engineered disc replacement. A new Penn Medicine study published in Science Translational Medicine provides compelling translational evidence that the cells of patients suffering from neck and back pain could be used to […]

A drug originally developed for prostate cancer may have exciting potential for treating Parkinson’s. The study, funded by Parkinson’s UK, suggests that the drug, tasquinimod, which is not yet on the market, works by controlling genes that may cause Parkinson’s. This happens when the drug interacts with a protein inside […]

Women who experience pregnancy loss and do not go on to have children are at greater risk of cardiovascular disease, such as heart disease and stroke, compared with women who have only one or two children, according to new research from the University of Cambridge and the University of North […]

In two papers published in the journal Cell, researchers from multiple Princeton departments report on the conditions that lead to the formation of membraneless organelles and the impact that the formation has on cellular DNA. Clifford Brangwynne, associate professor of chemical and biological engineering and leader of the research teams, said the […]

Mutations in the BRCA1 and BRCA2 genes pose a serious risk for breast and ovarian cancer because they endanger the genomic stability of a cell by interfering with homologous recombination repair (HR), a key mechanism for accurately repairing harmful double-stranded breaks in DNA. Without the ability to use HR to […]

A class of cancer drugs called protein kinase inhibitors is one of the most effective treatments for melanoma. However, in many cases, tumors eventually become resistant to the drugs and cause a relapse in the patient. A new study from MIT suggests that combining kinase inhibitors with experimental drugs known […]

A randomized clinical trial involving 97 medical centers in 20 countries, including Moores Cancer Center at UC San Diego Health, found that treating patients who have chemotherapy-resistant head and neck cancer with the immunotherapy drug pembrolizumab is more effective and less toxic than standard chemotherapy, reports an international team of […]