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Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments, according to a new study from researchers in the Abramson Cancer Center (ACC) at the University of Pennsylvania. Changing the microenvironment from so-called T cell […]

A small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the brains of Alzheimer’s disease patients. If perfected in humans, the technique could be used as an alternative approach to immunotherapy and used to treat other diseases caused by similar […]

Groundbreaking research from Tel Aviv University may lead to a significant breakthrough in the battle against deadly brain cancer. TAU researchers have identified a failure in the brain’s immune system that leads to the amplification of cell division and the spread of glioblastoma cancer cells. The failure results partially from the secretion […]

High expression levels of the gene TRIM63 can serve as an accurate and sensitive biomarker of a subtype of kidney cancer known as microphthalmia-associated transcription factor family aberration-associated renal cell carcinomas — or MiTF renal cell carcinoma. That’s according to a new, multi-institution study led by researchers at the University of Michigan Center for Translational […]

Alcohol-related liver disease is on the rise in the United States. Most strikingly, this epidemic is disproportionally affecting young, otherwise healthy, people, leading to rapid increases in alcohol-related liver disease deaths. “Changes in mortality rates for the alcohol-related liver disease vary significantly from state to state, so we think socioeconomic […]

Non-alcoholic fatty liver disease, NAFLD, is associated with several health risks. According to a new registry study led by researchers at Karolinska Institutet in Sweden, NAFLD is linked to a 17-fold increased risk of liver cancer. The findings, published in Hepatology, underscore the need for improved follow-up of NAFLD patients […]

Researchers here applied three months of a methionine restricted diet to old mice, and found that it greatly reduced age-related cognitive decline, as measured in maze tests. The methionine restricted animals perform more like young animals than like their unrestricted peers. Methionine is an essential amino acid essential to all […]

A new source of energy expending brown fat cells has been uncovered by Harvard Medical School researchers at Joslin Diabetes Center, which they said points towards potential new therapeutic options for obesity. According to the new report, published in Nature Metabolism, the key lies in the expression of a receptor […]

The University of Toronto’s Aleksandra Stanimirovic is currently leading a study that, she says, underscores the reason she chose to become a health researcher as opposed to a physician. The project focuses on a screening program for diabetic retinopathy – a complication of diabetes that can lead to blindness – among women from lower socio-economic groups. She […]

Targeting the tumour environment may help improve treatments for breast cancers affecting pregnant women and young mothers. New research led by the Garvan Institute of Medical Research has revealed how breast cancer cells that develop during or after pregnancy change their environment to form more aggressive tumours. In experimental models […]

Researchers have uncovered how antibodies that are specialised to different immune ‘disposal systems’ become the dominant form in the bloodstream, a process that is critical to our immune system’s ability to destroy pathogens and a key objective for the development of effective vaccines. Findings led by the Garvan Institute of […]

University of Manchester scientists have discovered a persistent alteration in the immune system of patients, six months after they have been hospitalised for Covid-19, which could be associated with poorer health outcomes. The study, published in the journal Med, examines the impact of a SARS-CoV-2 infection on the immune system of […]