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When healthcare professionals treat patients suffering from advanced cancers, they usually need to use a combination of different therapies. In addition to cancer surgery, the patients are often treated with radiation therapy, medication, or both. Medication can be combined, with different drugs acting on different cancer cells. Combinatorial drug therapies […]

A team of researchers at the Case Western Reserve University School of Medicine has taken a major step toward understanding the mechanisms involved in the formation of large clumps of tau protein, a hallmark of Alzheimer’s disease and several other neurodegenerative disorders. Their findings may help to better understand the […]

If stem cell science were bread baking, then working with pluripotent stem cells would be like starting with flour, water and yeast. Transforming those base materials into a delicious loaf of bread requires knowing which ingredients to add and how to manipulate the dough and its environment, such as by mixing […]

In mouse study, loss of molecule contributes to disease while surplus reduces symptoms. Osteoarthritis is one of the most common problems associated with ageing, and although there are therapies to treat the pain that results from the breakdown of the cartilage that cushions joints, there are no available therapies to […]

Millions of sperm enter the race to fertilize, but only one wins the sprint to the egg. Now Yale researchers have discovered that these winning sperm possess a few key molecular characteristics that differentiate them from those left behind, they report in the journal eLife. Sperm tails are lined with […]

A team co-led by a scientist at the University of California, Riverside, has developed a method to study how HIV mutates to escape the immune system in multiple individuals, which could inform HIV vaccine design. HIV, which can lead to AIDS, evolves rapidly and attacks the body’s immune system. Genetic mutations in […]

University of Minnesota researchers have discovered a potential target for the research and development of future therapies to mitigate the symptoms of a series of genetic disorders called laminopathies. Laminopathies cause a wide variety of conditions in humans, from skeletal muscular dystrophy and neuropathy to premature ageing. In a study […]

Just a few doses of an experimental drug can reverse age-related declines in memory and mental flexibility in mice, according to a new study by UC San Francisco scientists. The drug, called ISRIB, has already been shown in laboratory studies to restore memory function months after traumatic brain injury (TBI), reverse […]

Healthy cells and cells with Type 2 diabetes use completely different pathways to manage blood sugar levels, according to results from a study in mice. Researchers used a trans-omic approach, combining data from genes (transcriptomics) and metabolites (metabolomics) to identify and connect the many separate processes involved in responding to […]

Neuroscientists don’t know precisely what brain circuits control wakefulness and sleep, nor exactly how drugs for general anaesthesia affect those circuits. But a new study from Penn Medicine researchers brings neuroscience a step closer to solving that important conundrum. A team of researchers from the Perelman School of Medicine at […]

As time goes by, the tips of your chromosomes—called telomeres—become shorter. This process has long been viewed as an unwanted side-effect of ageing, but a recent study shows it is in fact good for you. “Telomeres protect the genetic material,” says Titia de Lange, Leon Hess Professor at Rockefeller. “The DNA […]

About 25 per cent of the U.S. population suffers from fatty liver disease, a condition that can lead to fibrosis of the liver and, eventually, liver failure. Currently, there is no easy way to diagnose either fatty liver disease or liver fibrosis. However, MIT engineers have now developed a diagnostic […]