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Adolescents who have poor cardiorespiratory fitness or are obese have an increased risk of developing cardiovascular disease later in life, serious enough to qualify them for disability pension due to a chronically reduced work capacity. The findings also suggest that a small improvement in fitness is associated with a lower […]

A team led by Case Western Reserve University School of Medicine researchers has made two major discoveries involving psoriasis, a chronic and debilitating skin disease with no known cure. The researchers found that an overabundance of a protein known as KLK6 can produce and worsen the skin inflammation characteristic of […]

Some bacterial pathogens cause damage in the genomes of their infected cells which could lead to the initiation of cancer. While it is difficult to link an infection with an onset of cancer that arises many years later in life, researchers have been looking for definitive proof that such links […]

Plant biologists have long sought a deeper understanding of foundational processes involving kinases, enzymes that catalyze key biological activities in proteins. Analyzing the processes underlying kinases in plants takes on greater urgency in today’s environment increasingly altered by climate warming. Certain “SnRK2” kinases (sucrose-non-fermenting-1-related protein kinase-2s) are essential since they […]

For more than 40 years, scientists and commercial companies have been recreating human skin in laboratories around the world. Yet all of these products lack important aspects of normal skin–hair, nerves, and fat. In new research, cultured human skin cells embedded with fat and nerves and capable of growing hair […]

With few exceptions, the worldwide community of clinics offering first generation stem cell therapies is not usually a source of reliable data. They don't tend to conduct trials or even much report on the results of their work. Further, the stem cell therapies used can vary enormously in effectiveness. Cells are fickle […]

One of the many interesting approaches to targeting cancer cells for destruction is the use of viruses that are largely innocuous to humans, but replicate preferentially in cells exhibiting the characteristics of cancer, such as continual cellular replication. Researchers here demonstrate a way to engineer a virus to require the biochemistry of […]

Today I'll point out an example of drug reuse and autophagy upregulation. The processes of autophagy are responsible for recycling molecular waste and broken cellular structures. Autophagy is upregulated in response to stress placed upon cells, whether by heat, cold, lack of nutrients, a toxic local environment, and so forth. This is […]

Some people get better from COVID-19 quicker than others. This is because of several factors, one of which is the condition of the immune system. People with rheumatic diseases such as arthritis take immunosuppressant medications. Are they at a bigger COVID-19 risk? Scientists from UCL decided to look into it. […]

Researchers from Alberta, California and Colorado Combine 3D Imaging and Machine Learning to Create Prototype Diagnostic Tool. Most children with rare genetic diseases spend years undergoing medical tests and waiting for a diagnosis – a long, exhausting process that takes its toll on children and their families. Almost half of […]

It’s summer and you might want to enjoy the sun a little bit more. However, sun’s UV rays may make you brown, but they may also give you cancer. Scientists from the University of Queensland conducted a research and found that targeting large clones of skin cells caused by ultraviolet […]

Cancer cells can turn on error-prone DNA copy pathways to adapt to cancer treatment, a breakthrough study published in the journal Science has revealed. Bacteria use the same process, termed stress-induced mutagenesis, to develop antibiotic resistance. The cells of the human body are constantly dividing, and each time we need to copy […]