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Extremely old people have such high mortality rates that studies such as this one here become practical, answering the question of how the gut microbiome changes in the final decline into death. It is well established that the gut microbiome is influential on health, and undergoes detrimental changes across the […]

Immunotherapies for cancer — treatments that prime the immune system to attack tumors — are valuable weapons in the anti-cancer arsenal. But some cancers are more difficult to target with this strategy than others. Today, scientists report a new type of immunotherapy that dramatically extends the survival of mice that […]

Researchers at the Stanford University School of Medicine have discovered a way to regenerate, in mice and human tissue, the cushion of cartilage found in joints. Loss of this slippery and shock-absorbing tissue layer, called articular cartilage, is responsible for many cases of joint pain and arthritis, which afflicts more than 55 […]

Electrical stimulation a week before surgery causes nerves to regenerate three to five times faster, leading to better outcomes. A University of Alberta researcher has found a treatment that increases the speed of nerve regeneration by three to five times, leading to much better outcomes for trauma surgery patients. “We […]

How we adapt to aging late in life may be genetically influenced, according to a study led by a psychologist at the University of California, Riverside. The research, published in Aging Cell, has implications for how epigenetic factors related to aging. Epigenesis is a process in which chemicals attached to DNA […]

CNRS researchers at the Institut Curie have recently shown that cancer cells use a membrane protein that has been known for several decades to internalise iron. Published in Nature Chemistry (August 3rd, 2020), this work shows that the absorbed iron allows cancer cells to acquire metastatic properties. Biologists knew CD44 […]

When people say “cardiovascular disease” in the context of blood cholesterol, they mean atherosclerosis. This is the name given to the build up of fatty deposits that narrow and weaken blood vessels, leading to heart failure and ultimately some form of disabling or fatal rupture – a stroke or heart […]

Every year, 150 to 300 children in the United States are diagnosed with diffuse intrinsic pontine gliomas (DIPGs), aggressive and lethal tumors that grow deep inside the brain, for which there are no cures. In a study funded by the National Institutes of Health, researchers showed that experimental drugs designed to […]

Opioid use among women trying to conceive may be associated with a lower chance of pregnancy, suggests a National Institutes of Health study. Moreover, opioid use in early pregnancy may be associated with a greater chance of pregnancy loss. The study appears in Epidemiology. “Our findings indicate that women who […]

Nearly three-quarters of older adults with dementia have filled prescriptions for medicines that act on their brain and nervous system, but aren’t designed for dementia, a new study shows. That’s despite the special risks that such drugs carry for older adults – and the lack of evidence that they actually ease […]

A Garvan-developed platform is providing researchers access to genomic data that will help drive discoveries in severe mitochondrial and brain disorders. Medical researchers from across the globe will gain new insight into some of the most devastating inherited conditions, thanks to anonymized genomic and clinical summary data made available by […]

A research team at the Max Planck Institute for Molecular Genetics in Berlin has explored the role of factors in embryonic development that do not alter the sequence of DNA, but only epigenetically modify its “packaging”. In the scientific journal Nature, they describe how regulatory mechanisms contribute to the formation of […]