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So-called “triple-negative” breast cancer is a particularly aggressive and difficult-to-treat form. It accounts for only about 10 percent of breast cancer cases, but is responsible for about 25 percent of breast cancer fatalities. Triple-negative breast cancer earns its name because, unlike other breast cancer subtypes, its cells test negative for […]

Cancer immunotherapy drugs have had notable but limited success because in many cases, tumors develop resistance to treatment. But researchers at Yale and Stanford have identified an experimental antibody that overcomes this problem by targeting a wider range of immune cells linked to tumor growth. Existing cancer immunotherapies act on only a […]

Using CRISPR genome editing, the team took the genetic engineering of killer T-cells one step further by removing their non-cancer specific receptors and replacing them with ones that would recognise specific cancer cells and destroy them. Dr Mateusz Legut from Cardiff University, who led the study while undertaking a Cancer […]

Catching cancer early can make all the difference for successful treatment. A common screening practice measures tumor growth with X-ray computed tomography (CT), which takes a series of cross-section images of the body. Before they are used in clinics, researchers test multiple CT imaging techniques with standard objects called “phantoms,” […]

Doctors have many drugs available to treat multiple myeloma, a type of blood cancer. However, there is no way to predict, by genetic markers or other means, how a patient will respond to a particular drug. This can lead to months of treatment with a drug that isn’t working. Researchers […]

“The biological clock ensures that a plant times its metabolism according to the environment,” says Dorothee Staiger. “Thus enabling it to directly use the first rays of sunlight for photosynthesis to produce carbohydrates, for example.” As the Nobel Prize winners have shown, individual genes in the genome of plants, animals […]

Since it first evolved in the common ancestor to multicellular animals some one billion years ago, the p53 family of genes has played the role of genomic guardian for countless organisms. So essential is its task—to protect the DNA of cells from damage and stress—that some form of p53 can […]

Folding your laundry or doing the dishes might not be the most enjoyable parts of your day. But simple activities like these may help prolong your life, according to the findings of a new study in older women led by the University at Buffalo. In the U.S. study of more […]

Nevan Krogan, PhD, is a mapmaker, but the object of his exploration is not any newfound continent or alien world. Instead, he and his colleagues map cells. Rather than cities, towns and interstates, these maps show proteins, genes, and the shifting, convoluted network of interactions between them. Learning to read […]

Scientists have created mini biological models of human primary liver cancers, known as organoids, in the lab for the first time. In a paper published in Nature Medicine, the tiny laboratory models of tumours were used to identify a new drug that could potentially treat certain types of liver cancer. Primary liver cancer […]

Cornell researchers have taken a major step toward answering a key question in cancer research: Why is testicular cancer so responsive to chemotherapy, even after it metastasizes? Professional cyclist Lance Armstrong, for example, had testicular cancer that spread to his lung and brain, yet he made a full recovery after […]

Harvard Medical School researchers at Boston Children’s Hospital have reversed type 1 diabetes in mice by infusing blood stem cells pretreated to produce more of a protein called PD-L1, which is deficient in mice and people with type 1 diabetes. The stem cells curbed the autoimmune reaction in cells from […]