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A new method of screening thousands of drugs in freshly collected human tumor cells could help identify which of the drugs are most likely to be effective against those cancers, report Harvard Medical School researchers based at Dana-Farber Cancer Institute and the Laboratory of Systems Pharmacology at HMS in a study published […]

DNA from uterine cells of women with endometriosis has different chemical modifications, compared to the DNA of women who do not have the condition, according to researchers funded by the National Institutes of Health. The changes involve DNA methylation — the binding of compounds known as methyl groups to DNA […]

Combining more healthy lifestyle behaviors was associated with a substantially lower risk for Alzheimer’s disease in a study that included data from nearly 3,000 research participants. Those who adhered to four or all of the five specified healthy behaviors were found to have a 60% lower risk of Alzheimer’s. The […]

An experimental drug that has been shown to improve the function of diseased and aged mitochondria binds to 12 key proteins involved in energy production, researchers at the University of Washington School of Medicine have found. The drug, elamipretide, also called SS-31, has shown promise for treating rare inherited diseases […]

The benefits of the prostate-specific antigen (PSA) test to screen men for prostate cancer may be greater than the harm, according to a study published in the New England Journal of Medicine. Genitourinary cancer specialists from Seattle Cancer Care Alliance, University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, […]

Vanderbilt University’s Warren Center for Neuroscience Drug Discovery has entered into an exclusive worldwide licensing and collaboration agreement with San Diego-based ACADIA Pharmaceuticals Inc., which will seek to develop and commercialize treatments for central nervous system disorders, such as Alzheimer’s disease and schizophrenia. This collaboration will focus on positive allosteric modulators (PAMs) of […]

A neuroscientist’s neon pink arm cast led him and fellow researchers at Washington University School of Medicine in St. Louis to discover previously undetected neuronal pulses in the human brain that activate after an immobilizing illness or injury. The pulses appeared on MRI scans used to measure the brain activity […]

A new study by researchers at UCSF Benioff Children’s Hospitals and St. Jude Children’s Research Hospital have identified what they believe to be a key reason behind patients’ treatment-resistance in the rare inflammatory disorder HLH. The finding could offer additional insights into other immune conditions, including a type of childhood […]

Research from the Department of Kinesiology at McMaster University has found that the practical advantages of high-intensity interval training (HIIT), or short bursts of all-out exercise, could be especially beneficial for people who have experienced spinal cord injuries (SCI). While many studies have proven the benefits of HIIT for the […]

A Rice University lab’s project to make better fluorescent tags has turned into a method to kill tumors. Switching one atom in the tag does the trick. Rice chemist Han Xiao and his colleagues found that replacing a single oxygen atom with a sulfur atom in a common fluorophore turns it into a photosensitizing molecule. When […]

Like finding that needle in the haystack every time, your T cells manage what seems like an improbable task: quickly finding a few invaders among the many imposters in your body to trigger its immune response. T cells have to react fast and do so nearly perfectly to protect people from diseases. […]

The brain and its surrounding blood vessels exist in a close relationship. The vessels supply the energy-hungry neuronal cells with nutrients. Researchers from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have now discovered how cells of the blood vessels sense the metabolic condition of the brain and […]