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The two used methods for detecting amyloid pathology in Alzheimer's disease do not give unambiguous results, with the risk of incorrect or delayed care interventions. Now, researchers at Karolinska Institutet have found genetic explanations for the differences. The study is published in Molecular Psychiatry and may be important for more […]

For people in wealthy countries, diarrhea is usually nothing more than an uncomfortable inconvenience for a few days. But for a poor child in a developing country, repeated bouts of diarrhea can lead to serious health consequences such as malnutrition, stunted growth and cognitive deficits. Researchers at Washington University School […]

Epidemics and pandemics are not equal-opportunity killers. Seen through the archaeological record, incomplete as it may be, these waves of death victimized the marginalized and most vulnerable populations wherever they struck. In the U.S., the COVID-19 pandemic appears to be no different, striking Indigenous, Black and Latinx communities at far […]

CRISPR-Cas9 makes it easy to knock out or tweak a single gene to determine its effect on an organism or cell, or even another gene. But what if you could perform several thousand experiments at once, using CRISPR to tweak every gene in the genome individually and quickly see the […]

Memory loss associated with Alzheimer’s disease (AD) may be able to be restored by inhibiting certain enzymes involved in abnormal gene transcription, according to a preclinical study by researchers at the University at Buffalo. The findings could pave the way toward new treatments for Alzheimer’s disease. The paper will be […]

On a late summer day in 1953, a young man who would soon be known as patient H.M. underwent experimental surgery. In an attempt to treat his debilitating seizures, a surgeon removed portions of his brain, including part of a structure called the hippocampus. The seizures stopped. Unfortunately, for patient […]

Obesity has been linked to increased risk for over a dozen different types of cancer, as well as worse prognosis and survival. Over the years, scientists have identified obesity-related processes that drive tumour growth, such as metabolic changes and chronic inflammation, but a detailed understanding of the interplay between obesity […]

An international team of researchers has connected specific genetic regions which influence facial features. This means they can see the signals of normal facial features in the genome – but it is also hoped their work can shed light on craniofacial malformations such as cleft lip and palate. The findings […]

The lab of Kris Saha at the University of Wisconsin–Madison has developed an innovative combination of gene-editing tools and computational simulations that can be used to develop new strategies for editing genes associated with genetic disorders. In proof-of-concept experiments, the lab’s researchers efficiently corrected multiple mutations responsible for a rare metabolic disorder, known […]

Big changes are taking place in the research laboratories at DTU Biosustain on Lyngby Campus—but it requires a microscope to spot them, as the changes are occurring in microorganisms such as the bacterium, Streptomyces.  The bacterium is known to produce antimicrobial agents. In the New Bioactive Compound Section, researchers are […]

In his first year of graduate school, Rice University biochemist Zachary Wright discovered something hidden inside a common piece of cellular machinery that’s essential for all higher-order life from yeast to humans. What Wright saw in 2015 — subcompartments inside organelles called peroxisomes — is described in a study published in Nature […]

The ability of certain fish to heal damage to their hearts could lead to new treatments for patients who have suffered heart attacks and may also help to unravel how the lifestyle of our parents and grandparents can affect our own heart health. The human heart cannot heal itself. After […]