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Inside a tumor, chatter abounds. Multiple cell types are constantly communicating with each other, exchanging various types of information. Some are working together against the tumor, while others help the tumor grow. Researchers have a good handle on who the main players are, but it can be difficult to tell […]

Martin Monti, a Professor of Psychology and Neurosurgery at UCLA, and colleagues have recently published a paper in the journal Brain Stimulation, describing their success in jump-starting the brains of two patients in a long-term “minimally conscious state”. While Monti had already performed a similar procedure on a 25-year-old man […]

The problem of protein folding is one of the most important and hard tasks in computational biochemistry. Recently, deep learning models, such as AlphaFold, were shown to be more effective in this task than classical techniques. The likely advance of quantum computing could help to improve current algorithms further. A […]

McMaster researchers have established in lab settings that a novel combination of two forms of immunotherapy can be highly effective for treating lung cancer, which causes more deaths than any other form of cancer. The new treatment, yet to be tested on patients, uses one form of therapy to kill […]

A team of international researchers who study how gene mutations associated with autism interfere with social behaviour have found injections of the hormone oxytocin can normalize brain activity. The findings, which were presented recently at the 2021 Society for Neuroscience Global Connectome, point to the potential of oxytocin—known to influence behaviours […]

Special immune cells found in the brain, microglia, play a key role in the processes that make you feel uneasy and depressed in correlation with inflammation. The findings from a new study on mice suggest that microglial cells contribute to the negative mood experienced during several neurological diseases. David Engblom’s […]

Many forms of mild cellular stress produce benefits to health because they trigger the more efficient operation of cellular maintenance processes such as autophagy. That in turn causes better cell and tissue function, and thus improved health. This stress response and benefit is known as hormesis, and has been robustly […]

Scientists at the National Eye Institute (NEI) have developed a promising gene therapy strategy for a rare disease that causes severe vision loss in childhood. A form of Leber congenital amaurosis, the disease is caused by autosomal-dominant mutations in the CRX gene, which are challenging to treat with gene therapy.  The scientists […]

An innovative approach to treating bone tumors — starving cancer cells of the energy they need to grow — could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, suggests a new study from Washington University School of Medicine in St. […]

Researchers at Children’s Hospital of Philadelphia and the School of Engineering and Applied Science at the University of Pennsylvania have identified ionizable lipid nanoparticles that could be used to deliver mRNA as part of fetal therapy. The proof-of-concept study, published in Science Advances, engineered and screened a number of lipid nanoparticle […]

Alzheimer’s disease, multiple sclerosis, autism, schizophrenia and many other neurological and psychiatric conditions have been linked to inflammation in the brain. There’s growing evidence that immune cells and molecules play a key role in normal brain development and function as well. But at the core of the burgeoning field of […]

Many genetic mutations have been found to be associated with a person’s risk of developing Parkinson’s disease. Yet for most of these variants, the mechanism through which they act remains unclear. Now a new study in Nature led by a team from the University of Pennsylvania has revealed how two different variations—one […]